| Summary: | <p>Abstract</p> <p>Background</p> <p>The A/H1N1 2009 influenza pandemic revealed that operational issues of school closure interventions, such as <it>when </it>school closure should be initiated (activation trigger), <it>how long </it>schools should be closed (duration) and <it>what type </it>of school closure should be adopted, varied greatly between and within countries. Computer simulation can be used to examine school closure intervention strategies in order to inform public health authorities as they refine school closure guidelines in light of experience with the A/H1N1 2009 pandemic.</p> <p>Methods</p> <p>An individual-based simulation model was used to investigate the effectiveness of school closure interventions for influenza pandemics with R<sub>0 </sub>of 1.5, 2.0 and 2.5. The effectiveness of <it>individual school closure </it>and <it>simultaneous school closure </it>were analyzed for 2, 4 and 8 weeks closure duration, with a daily diagnosed case based intervention activation trigger scheme. The effectiveness of combining antiviral drug treatment and household prophyaxis with school closure was also investigated.</p> <p>Results</p> <p>Illness attack rate was reduced from 33% to 19% (14% reduction in overall attack rate) by 8 weeks school closure activating at 30 daily diagnosed cases in the community for an influenza pandemic with R<sub>0 </sub>= 1.5; when combined with antivirals a 19% (from 33% to 14%) reduction in attack rate was obtained. For R<sub>0 </sub>>= 2.0, school closure would be less effective. An 8 weeks school closure strategy gives 9% (from 50% to 41%) and 4% (from 59% to 55%) reduction in attack rate for R<sub>0 </sub>= 2.0 and 2.5 respectively; however, school closure plus antivirals would give a significant reduction (~15%) in over all attack rate. The results also suggest that an <it>individual school closure </it>strategy would be more effective than <it>simultaneous school closure</it>.</p> <p>Conclusions</p> <p>Our results indicate that the particular school closure strategy to be adopted depends both on the disease <it>severity</it>, which will determine the <it>duration </it>of school closure deemed acceptable, and its <it>transmissibility</it>. For epidemics with a <it>low </it>transmissibility (R<sub>0 </sub>< 2.0) and/or <it>mild </it>severity, individual school closures should begin once a daily community case count is exceeded. For a <it>severe</it>, <it>highly transmissible </it>epidemic (R<sub>0 </sub>>= 2.0), long duration school closure should begin as soon as possible and be combined with other interventions.</p>
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