Distribution of glutathione S-transferase GSTM1 and GSTT1 null phenotypes in Brazilian Amerindians

• Main Authors: Maria de Nazaré Klautau-Guimarães, Cássia de Oliveira Hiragi, Renata Ferreira D'Ascenção, Silviene Fabiana Oliveira, Cesar Koppe Grisolia, Ana Hatagima, Íris Ferrari
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Genética 2005-03-01
• Series: Genetics and Molecular Biology
• Subjects: Munduruku; glutathione S-transferase; Kayabi; null alleles
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000100005

The distribution of glutathione S-transferase (GST) GSTM1 and GSTT1 null phenotype frequencies in two Brazilian Amerindian tribes, the Munduruku tribe from Missão Cururu village (79 individuals) and the Kayabi tribe (41 individuals), was analyzed by polymerase chain reaction (PCR) amplification. The GST null phenotype frequencies for the Munduruku sample were 0% for GSTM1 and 27% for GSTT1 while for the Kayabi sample the null phenotype frequencies were 27% for GSTM1 and 29% for GSTT1. This is the first report of the absence of the GSTM1 null phenotype in any ethnic group.