A unique volatile signature distinguishes malaria infection from other conditions that cause similar symptoms
Abstract Recent findings suggest that changes in human odors caused by malaria infection have significant potential as diagnostic biomarkers. However, uncertainty remains regarding the specificity of such biomarkers, particularly in populations where many different pathological conditions may elicit...
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2021-07-01
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Online Access: | https://doi.org/10.1038/s41598-021-92962-x |
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doaj-bf0356d8879144dfae3e92ae9f1e79f72021-07-11T11:29:32ZengNature Publishing GroupScientific Reports2045-23222021-07-011111910.1038/s41598-021-92962-xA unique volatile signature distinguishes malaria infection from other conditions that cause similar symptomsHannier Pulido0Nina M. Stanczyk1Consuelo M. De Moraes2Mark C. Mescher3Department of Environmental Systems ScienceDepartment of Environmental Systems ScienceDepartment of Environmental Systems ScienceDepartment of Environmental Systems ScienceAbstract Recent findings suggest that changes in human odors caused by malaria infection have significant potential as diagnostic biomarkers. However, uncertainty remains regarding the specificity of such biomarkers, particularly in populations where many different pathological conditions may elicit similar symptoms. We explored the ability of volatile biomarkers to predict malaria infection status in Kenyan schoolchildren exhibiting a range of malaria-like symptoms. Using genetic algorithm models to explore data from skin volatile collections, we were able to identify malaria infection with 100% accuracy among children with fever and 75% accuracy among children with other symptoms. While we observed characteristic changes in volatile patterns driven by symptomatology, our models also identified malaria-specific biomarkers with robust predictive capability even in the presence of other pathogens that elicit similar symptoms.https://doi.org/10.1038/s41598-021-92962-x |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hannier Pulido Nina M. Stanczyk Consuelo M. De Moraes Mark C. Mescher |
spellingShingle |
Hannier Pulido Nina M. Stanczyk Consuelo M. De Moraes Mark C. Mescher A unique volatile signature distinguishes malaria infection from other conditions that cause similar symptoms Scientific Reports |
author_facet |
Hannier Pulido Nina M. Stanczyk Consuelo M. De Moraes Mark C. Mescher |
author_sort |
Hannier Pulido |
title |
A unique volatile signature distinguishes malaria infection from other conditions that cause similar symptoms |
title_short |
A unique volatile signature distinguishes malaria infection from other conditions that cause similar symptoms |
title_full |
A unique volatile signature distinguishes malaria infection from other conditions that cause similar symptoms |
title_fullStr |
A unique volatile signature distinguishes malaria infection from other conditions that cause similar symptoms |
title_full_unstemmed |
A unique volatile signature distinguishes malaria infection from other conditions that cause similar symptoms |
title_sort |
unique volatile signature distinguishes malaria infection from other conditions that cause similar symptoms |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-07-01 |
description |
Abstract Recent findings suggest that changes in human odors caused by malaria infection have significant potential as diagnostic biomarkers. However, uncertainty remains regarding the specificity of such biomarkers, particularly in populations where many different pathological conditions may elicit similar symptoms. We explored the ability of volatile biomarkers to predict malaria infection status in Kenyan schoolchildren exhibiting a range of malaria-like symptoms. Using genetic algorithm models to explore data from skin volatile collections, we were able to identify malaria infection with 100% accuracy among children with fever and 75% accuracy among children with other symptoms. While we observed characteristic changes in volatile patterns driven by symptomatology, our models also identified malaria-specific biomarkers with robust predictive capability even in the presence of other pathogens that elicit similar symptoms. |
url |
https://doi.org/10.1038/s41598-021-92962-x |
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