Caffeine and Parkinson’s Disease: Multiple Benefits and Emerging Mechanisms
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, characterized by dopaminergic neurodegeneration, motor impairment and non-motor symptoms. Epidemiological and experimental investigations into potential risk factors have firmly established that dietary factor caffeine, t...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-12-01
|
Series: | Frontiers in Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2020.602697/full |
id |
doaj-bf03de4cfaa74596a6fb3332a334fbfd |
---|---|
record_format |
Article |
spelling |
doaj-bf03de4cfaa74596a6fb3332a334fbfd2020-12-17T06:09:23ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-12-011410.3389/fnins.2020.602697602697Caffeine and Parkinson’s Disease: Multiple Benefits and Emerging MechanismsXiangpeng Ren0Xiangpeng Ren1Xiangpeng Ren2Jiang-Fan Chen3Jiang-Fan Chen4Molecular Neuropharmacology Lab, School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, ChinaState Key Laboratory of Ophthalmology, Optometry and Visual Science, Wenzhou, ChinaDepartment of Biochemistry, Medical College, Jiaxing University, Jiaxing, ChinaMolecular Neuropharmacology Lab, School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, ChinaState Key Laboratory of Ophthalmology, Optometry and Visual Science, Wenzhou, ChinaParkinson’s disease (PD) is the second most common neurodegenerative disorder, characterized by dopaminergic neurodegeneration, motor impairment and non-motor symptoms. Epidemiological and experimental investigations into potential risk factors have firmly established that dietary factor caffeine, the most-widely consumed psychoactive substance, may exerts not only neuroprotective but a motor and non-motor (cognitive) benefits in PD. These multi-benefits of caffeine in PD are supported by convergence of epidemiological and animal evidence. At least six large prospective epidemiological studies have firmly established a relationship between increased caffeine consumption and decreased risk of developing PD. In addition, animal studies have also demonstrated that caffeine confers neuroprotection against dopaminergic neurodegeneration using PD models of mitochondrial toxins (MPTP, 6-OHDA, and rotenone) and expression of α-synuclein (α-Syn). While caffeine has complex pharmacological profiles, studies with genetic knockout mice have clearly revealed that caffeine’s action is largely mediated by the brain adenosine A2A receptor (A2AR) and confer neuroprotection by modulating neuroinflammation and excitotoxicity and mitochondrial function. Interestingly, recent studies have highlighted emerging new mechanisms including caffeine modulation of α-Syn degradation with enhanced autophagy and caffeine modulation of gut microbiota and gut-brain axis in PD models. Importantly, since the first clinical trial in 2003, United States FDA has finally approved clinical use of the A2AR antagonist istradefylline for the treatment of PD with OFF-time in Sept. 2019. To realize therapeutic potential of caffeine in PD, genetic study of caffeine and risk genes in human population may identify useful pharmacogenetic markers for predicting individual responses to caffeine in PD clinical trials and thus offer a unique opportunity for “personalized medicine” in PD.https://www.frontiersin.org/articles/10.3389/fnins.2020.602697/fullcaffeineParkinson’s diseaseα-synucleinadenosine A2A receptorautophagygut microbiota |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiangpeng Ren Xiangpeng Ren Xiangpeng Ren Jiang-Fan Chen Jiang-Fan Chen |
spellingShingle |
Xiangpeng Ren Xiangpeng Ren Xiangpeng Ren Jiang-Fan Chen Jiang-Fan Chen Caffeine and Parkinson’s Disease: Multiple Benefits and Emerging Mechanisms Frontiers in Neuroscience caffeine Parkinson’s disease α-synuclein adenosine A2A receptor autophagy gut microbiota |
author_facet |
Xiangpeng Ren Xiangpeng Ren Xiangpeng Ren Jiang-Fan Chen Jiang-Fan Chen |
author_sort |
Xiangpeng Ren |
title |
Caffeine and Parkinson’s Disease: Multiple Benefits and Emerging Mechanisms |
title_short |
Caffeine and Parkinson’s Disease: Multiple Benefits and Emerging Mechanisms |
title_full |
Caffeine and Parkinson’s Disease: Multiple Benefits and Emerging Mechanisms |
title_fullStr |
Caffeine and Parkinson’s Disease: Multiple Benefits and Emerging Mechanisms |
title_full_unstemmed |
Caffeine and Parkinson’s Disease: Multiple Benefits and Emerging Mechanisms |
title_sort |
caffeine and parkinson’s disease: multiple benefits and emerging mechanisms |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2020-12-01 |
description |
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, characterized by dopaminergic neurodegeneration, motor impairment and non-motor symptoms. Epidemiological and experimental investigations into potential risk factors have firmly established that dietary factor caffeine, the most-widely consumed psychoactive substance, may exerts not only neuroprotective but a motor and non-motor (cognitive) benefits in PD. These multi-benefits of caffeine in PD are supported by convergence of epidemiological and animal evidence. At least six large prospective epidemiological studies have firmly established a relationship between increased caffeine consumption and decreased risk of developing PD. In addition, animal studies have also demonstrated that caffeine confers neuroprotection against dopaminergic neurodegeneration using PD models of mitochondrial toxins (MPTP, 6-OHDA, and rotenone) and expression of α-synuclein (α-Syn). While caffeine has complex pharmacological profiles, studies with genetic knockout mice have clearly revealed that caffeine’s action is largely mediated by the brain adenosine A2A receptor (A2AR) and confer neuroprotection by modulating neuroinflammation and excitotoxicity and mitochondrial function. Interestingly, recent studies have highlighted emerging new mechanisms including caffeine modulation of α-Syn degradation with enhanced autophagy and caffeine modulation of gut microbiota and gut-brain axis in PD models. Importantly, since the first clinical trial in 2003, United States FDA has finally approved clinical use of the A2AR antagonist istradefylline for the treatment of PD with OFF-time in Sept. 2019. To realize therapeutic potential of caffeine in PD, genetic study of caffeine and risk genes in human population may identify useful pharmacogenetic markers for predicting individual responses to caffeine in PD clinical trials and thus offer a unique opportunity for “personalized medicine” in PD. |
topic |
caffeine Parkinson’s disease α-synuclein adenosine A2A receptor autophagy gut microbiota |
url |
https://www.frontiersin.org/articles/10.3389/fnins.2020.602697/full |
work_keys_str_mv |
AT xiangpengren caffeineandparkinsonsdiseasemultiplebenefitsandemergingmechanisms AT xiangpengren caffeineandparkinsonsdiseasemultiplebenefitsandemergingmechanisms AT xiangpengren caffeineandparkinsonsdiseasemultiplebenefitsandemergingmechanisms AT jiangfanchen caffeineandparkinsonsdiseasemultiplebenefitsandemergingmechanisms AT jiangfanchen caffeineandparkinsonsdiseasemultiplebenefitsandemergingmechanisms |
_version_ |
1724380124854353920 |