Nicolau Syndrome due to Penicillin Injection: A Report of 3 Cases without Long-Term Complication

Nicolau Syndrome due to Penicillin Injection: A Report of 3 Cases without Long-Term Complication

Nicolau syndrome (NS) or livedo-like dermatitis is a rare complication of injection of various medications such as penicillin. The pathophysiology of this events is not clear, but some hypotheses are suggested, such as sympathetic nerve stimulation, embolic occlusion, inflammation, or mechanical inj...

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Main Authors: Sara Memarian, Behdad Gharib, Mohammd Gharagozlou, Hosein Alimadadi, Zahra Ahmadinejad, Vahid Ziaee
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Case Reports in Infectious Diseases
Online Access:http://dx.doi.org/10.1155/2016/9082158
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spelling doaj-bf1d3c924abf45a0b4c223c805bcbe1e2020-11-24T21:45:11ZengHindawi LimitedCase Reports in Infectious Diseases2090-66252090-66332016-01-01201610.1155/2016/90821589082158Nicolau Syndrome due to Penicillin Injection: A Report of 3 Cases without Long-Term ComplicationSara Memarian0Behdad Gharib1Mohammd Gharagozlou2Hosein Alimadadi3Zahra Ahmadinejad4Vahid Ziaee5Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, IranGrowth and Development Research Center, Tehran University of Medical Sciences, Tehran, IranChildren’s Medical Center, Pediatric Center of Excellence, Tehran, IranChildren’s Medical Center, Pediatric Center of Excellence, Tehran, IranDepartment of Infectious Diseases, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, IranChildren’s Medical Center, Pediatric Center of Excellence, Tehran, IranNicolau syndrome (NS) or livedo-like dermatitis is a rare complication of injection of various medications such as penicillin. The pathophysiology of this events is not clear, but some hypotheses are suggested, such as sympathetic nerve stimulation, embolic occlusion, inflammation, or mechanical injury. In this paper we report 3 cases of NS following benzathine penicillin. Clinical symptoms improved in 2 cases during 2-month follow-up, but one of them had a residual necrosis in the distal phalanges of the toes.http://dx.doi.org/10.1155/2016/9082158
collection DOAJ
language English
format Article
sources DOAJ
author Sara Memarian
Behdad Gharib
Mohammd Gharagozlou
Hosein Alimadadi
Zahra Ahmadinejad
Vahid Ziaee
spellingShingle Sara Memarian
Behdad Gharib
Mohammd Gharagozlou
Hosein Alimadadi
Zahra Ahmadinejad
Vahid Ziaee
Nicolau Syndrome due to Penicillin Injection: A Report of 3 Cases without Long-Term Complication
Case Reports in Infectious Diseases
author_facet Sara Memarian
Behdad Gharib
Mohammd Gharagozlou
Hosein Alimadadi
Zahra Ahmadinejad
Vahid Ziaee
author_sort Sara Memarian
title Nicolau Syndrome due to Penicillin Injection: A Report of 3 Cases without Long-Term Complication
title_short Nicolau Syndrome due to Penicillin Injection: A Report of 3 Cases without Long-Term Complication
title_full Nicolau Syndrome due to Penicillin Injection: A Report of 3 Cases without Long-Term Complication
title_fullStr Nicolau Syndrome due to Penicillin Injection: A Report of 3 Cases without Long-Term Complication
title_full_unstemmed Nicolau Syndrome due to Penicillin Injection: A Report of 3 Cases without Long-Term Complication
title_sort nicolau syndrome due to penicillin injection: a report of 3 cases without long-term complication
publisher Hindawi Limited
series Case Reports in Infectious Diseases
issn 2090-6625
2090-6633
publishDate 2016-01-01
description Nicolau syndrome (NS) or livedo-like dermatitis is a rare complication of injection of various medications such as penicillin. The pathophysiology of this events is not clear, but some hypotheses are suggested, such as sympathetic nerve stimulation, embolic occlusion, inflammation, or mechanical injury. In this paper we report 3 cases of NS following benzathine penicillin. Clinical symptoms improved in 2 cases during 2-month follow-up, but one of them had a residual necrosis in the distal phalanges of the toes.
url http://dx.doi.org/10.1155/2016/9082158
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AT hoseinalimadadi nicolausyndromeduetopenicillininjectionareportof3caseswithoutlongtermcomplication
AT zahraahmadinejad nicolausyndromeduetopenicillininjectionareportof3caseswithoutlongtermcomplication
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