Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier

Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier

<p>Abstract</p> <p>Background</p> <p>Defects in the low density lipoprotein receptor-related protein-1 (LRP-1) and p-glycoprotein (Pgp) clearance of amyloid beta (Aβ) from brain are thought to contribute to Alzheimer’s disease (AD). We have recently shown that induction...

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Bibliographic Details
Main Authors: Erickson Michelle A, Hartvigson Pehr E, Morofuji Yoichi, Owen Joshua B, Butterfield D, Banks William A
Format: Article
Language:English
Published: BMC 2012-06-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
amyloid beta
blood–brain barrier
inflammation
lipopolysaccharide
LRP1
Pgp
ABCB1
MDR1
cerebrospinal fluid
Online Access:http://www.jneuroinflammation.com/content/9/1/150

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