Activation of DNA Damage Response Pathways during Lytic Replication of KSHV

Activation of DNA Damage Response Pathways during Lytic Replication of KSHV

Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of several human malignancies. Human tumour viruses such as KSHV are known to interact with the DNA damage response (DDR), the molecular pathways that recognise and repair lesions in cellular DNA. Here it is demonstrated that lyti...

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Bibliographic Details
Main Authors: Robert Hollingworth, George L. Skalka, Grant S. Stewart, Andrew D. Hislop, David J. Blackbourn, Roger J. Grand
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Viruses
Subjects:
Kaposi’s sarcoma-associated herpesvirus
KSHV
DNA damage response
DDR
lytic replication
ATM
ATR
DNA-PK
Online Access:http://www.mdpi.com/1999-4915/7/6/2752

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