Progressive Encephalomyelitis With Rigidity and Myoclonus With Thymoma: A Case Report and Literature Review

• Main Authors: Yana Su, Li Cui, Mingqin Zhu, Yixuan Liang, Ying Zhang
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2020-09-01
• Series: Frontiers in Neurology
• Subjects: progressive encephalomyelitis with rigidity and myoclonus; thymoma; anti-glycine receptor antibody; anti-glutamic acid decarboxylase antibodies; tumors
• Online Access: https://www.frontiersin.org/article/10.3389/fneur.2020.01017/full

Progressive encephalomyelitis with rigidity and myoclonus (PERM) is part of the variant type of the Stiff Person Syndrome (SPS) and is a rare neurological disease. We report here a patient with PERM who had thymoma and was positive for anti-glutamic acid decarboxylase (anti-GAD) antibodies. Her symptoms improved after treatment with hormones and gamma globulin. We also summarized the literature review of patients with PERM accompanied by tumors reported.