Floridoside suppresses pro-inflammatory responses by blocking MAPK signaling in activated microglia

• Main Authors: MinJeong Kim, Yong-Xin Li, Pradeep Dewapriya, BoMi Ryu, Se-Kwon Kim
• Format: Article
• Language: English
• Published: Korean Society for Biochemistry and Molecular Biology 2013-08-01
• Series: BMB Reports
• Subjects: Alzheimer’s disease; Floridoside; Laurencia undulata; Neuro-inflammation; Oxidative stress
• Online Access: http://bmbreports.org/jbmb/pdf.php?data=MTMxMDAyMTdAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni04JTVEMTMwODI4MjI0NV8lMjgzOTgtNDAzJTI5Qk1CXzEyLTIzNy5wZGY=
• ISSN: 1976-6696; 1976-670X

Inflammatory conditions mediated by activated microglia leadto chronic neuro-degenerative diseases such as Alzheimer’s,Parkinson’s, and Huntington’s diseases. This study wasconducted to determine the effect of floridoside isolated frommarine red algae Laurencia undulata on LPS (100 ng/ml)activated inflammatory responses in BV-2 microglia cells. Theresults show that floridoside has the ability to suppresspro-inflammatory responses in microglia by markedly inhibitingthe production of nitric oxide (NO) and reactive oxygen species(ROS). Moreover, floridoside down-regulated the protein andgene expression levels of iNOS and COX-2 by significantlyblocking the phosphorylation of p38 and ERK in BV-2 cells.Collectively, these results indicate that floridoside has thepotential to be developed as an active agent for the treatmentof neuro-inflammation. [BMB Reports 2013; 46(8): 398-403]