Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study
Whether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear regression-derived coefficients of the association of non-indexed and total l...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/2/580 |
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doaj-bf405694452944fa81539beb68db553b |
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| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Camilo G. Sotomayor Isidor Minović Manfred L. Eggersdorfer Ineke J. Riphagen Martin H. de Borst Louise H. Dekker Ilja M. Nolte Jan Frank Sander K.R. van Zon Sijmen A. Reijneveld Jan C. van der Molen Michel J. Vos Jenny E. Kootstra-Ros Ramón Rodrigo Ido P. Kema Gerjan J. Navis Stephan J.L. Bakker |
| spellingShingle |
Camilo G. Sotomayor Isidor Minović Manfred L. Eggersdorfer Ineke J. Riphagen Martin H. de Borst Louise H. Dekker Ilja M. Nolte Jan Frank Sander K.R. van Zon Sijmen A. Reijneveld Jan C. van der Molen Michel J. Vos Jenny E. Kootstra-Ros Ramón Rodrigo Ido P. Kema Gerjan J. Navis Stephan J.L. Bakker Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study Nutrients elderly vitamin e tocopherol total lipids insulin resistance syndrome one-carbon metabolism pyridoxal phosphate cobalamin folate homocysteine |
| author_facet |
Camilo G. Sotomayor Isidor Minović Manfred L. Eggersdorfer Ineke J. Riphagen Martin H. de Borst Louise H. Dekker Ilja M. Nolte Jan Frank Sander K.R. van Zon Sijmen A. Reijneveld Jan C. van der Molen Michel J. Vos Jenny E. Kootstra-Ros Ramón Rodrigo Ido P. Kema Gerjan J. Navis Stephan J.L. Bakker |
| author_sort |
Camilo G. Sotomayor |
| title |
Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study |
| title_short |
Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study |
| title_full |
Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study |
| title_fullStr |
Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study |
| title_full_unstemmed |
Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study |
| title_sort |
duality of tocopherol isoforms and novel associations with vitamins involved in one-carbon metabolism: results from an elderly sample of the lifelines cohort study |
| publisher |
MDPI AG |
| series |
Nutrients |
| issn |
2072-6643 |
| publishDate |
2020-02-01 |
| description |
Whether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear regression-derived coefficients of the association of non-indexed and total lipids-indexed vitamin E isoforms with clinical and laboratory characteristics pertaining to the lipid, metabolic syndrome, and one-carbon metabolism biological domains. We studied 1429 elderly subjects (non-vitamin supplement users, 60−75 years old, with low and high socioeconomic status) from the population-based LifeLines Cohort and Biobank Study. We found that the associations of tocopherol isoforms with lipids were inverted in total lipids-indexed analyses, which may be indicative of overcorrection. Irrespective of the methods of standardization, we consistently found positive associations of α-tocopherol with vitamins of the one-carbon metabolism pathway and inverse associations with characteristics related to glucose metabolism. The associations of γ-tocopherol were often opposite to those of α-tocopherol. These data suggest that tocopherol isoforms and one-carbon metabolism are related, with beneficial and adverse associations for α-tocopherol and γ-tocopherol, respectively. Whether tocopherol isoforms, or their interplay, truly affect the one-carbon metabolism pathway remains to be further studied. |
| topic |
elderly vitamin e tocopherol total lipids insulin resistance syndrome one-carbon metabolism pyridoxal phosphate cobalamin folate homocysteine |
| url |
https://www.mdpi.com/2072-6643/12/2/580 |
| work_keys_str_mv |
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doaj-bf405694452944fa81539beb68db553b2020-11-25T00:31:11ZengMDPI AGNutrients2072-66432020-02-0112258010.3390/nu12020580nu12020580Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort StudyCamilo G. Sotomayor0Isidor Minović1Manfred L. Eggersdorfer2Ineke J. Riphagen3Martin H. de Borst4Louise H. Dekker5Ilja M. Nolte6Jan Frank7Sander K.R. van Zon8Sijmen A. Reijneveld9Jan C. van der Molen10Michel J. Vos11Jenny E. Kootstra-Ros12Ramón Rodrigo13Ido P. Kema14Gerjan J. Navis15Stephan J.L. Bakker16Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsInstitute of Nutritional Sciences, University of Hohenheim, 70599 Stuttgart, GermanyDepartment of Health Sciences, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsDepartment of Health Sciences, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsMolecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago CP 8380453, ChileDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsWhether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear regression-derived coefficients of the association of non-indexed and total lipids-indexed vitamin E isoforms with clinical and laboratory characteristics pertaining to the lipid, metabolic syndrome, and one-carbon metabolism biological domains. We studied 1429 elderly subjects (non-vitamin supplement users, 60−75 years old, with low and high socioeconomic status) from the population-based LifeLines Cohort and Biobank Study. We found that the associations of tocopherol isoforms with lipids were inverted in total lipids-indexed analyses, which may be indicative of overcorrection. Irrespective of the methods of standardization, we consistently found positive associations of α-tocopherol with vitamins of the one-carbon metabolism pathway and inverse associations with characteristics related to glucose metabolism. The associations of γ-tocopherol were often opposite to those of α-tocopherol. These data suggest that tocopherol isoforms and one-carbon metabolism are related, with beneficial and adverse associations for α-tocopherol and γ-tocopherol, respectively. Whether tocopherol isoforms, or their interplay, truly affect the one-carbon metabolism pathway remains to be further studied.https://www.mdpi.com/2072-6643/12/2/580elderlyvitamin etocopheroltotal lipidsinsulin resistance syndromeone-carbon metabolismpyridoxal phosphatecobalaminfolatehomocysteine |