| Summary: | Objective: To study the correlation between shock index and inflammation, oxidative stress
as well as target organ damage in patients with sepsis. Methods: A total of 70 patients with
sepsis treated in our hospital between March 2013 and May 2016 were collected and divided
into no shock group (SI<0.5) (n=11), general shock group (0.5≤SI≤2) (n=42) and severe shock
group (SI>2.0) (n=17) according to the shock index (SI). Immediately after admission, serum
levels of inflammatory factors, oxidative stress indexes and liver function indexes were
detected. Results: Serum interleukin-1β (IL-1β), interleukin-8 (IL-8), tumor necrosis factor
α (TNF-α), advanced oxidation protein products (AOPPs), total bilirubin (TB), γ-glutamyl
transpeptidase (GGT) and alanine aminotransferase (ALT) levels of severe shock group and
general shock group were higher than those of no shock group while anti-inflammatory factors
interleukin-10 (IL-10), interleukin-13 (IL-13), soluble tumor necrosis factor receptor Ⅰ
(sTNF-RI), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) and catalase
(CAT) levels were lower than those of no shock group; serum IL-1β, IL-8, TNF-α, AOPPs,
TB, GGT and ALT levels of severe shock group were higher than those of general shock
group while IL-10, IL-13, sTNF-RI, CAT, GSH-Px and SOD levels were lower than those of
general shock group. Conclusion: The higher the shock index in patients with sepsis, the more
severe the inflammation, oxidative stress and target organ damage, and the two are positively
correlated.
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