Correlation between shock index and inflammation, oxidative stress as well as target organ damage in patients with sepsis
Objective: To study the correlation between shock index and inflammation, oxidative stress as well as target organ damage in patients with sepsis. Methods: A total of 70 patients with sepsis treated in our hospital between March 2013 and May 2016 were collected and divided into no shock group (SI...
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doaj-bf45486adcf046a186b12f1bd9efcebb2020-11-24T21:15:26ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12372017-04-012343639Correlation between shock index and inflammation, oxidative stress as well as target organ damage in patients with sepsisWei-Zhou Zhong0 Qing-Shan Liu1Yuan-Tong Ou2 Fu-Gang Gao3Cardiovascular Medicine Department, Bao’an Central Hospital of Shenzhen Guangdong Province, Shenzhen City, Guangdong Province, 518102Emergency Medicine Department, Bao’an Central Hospital of Shenzhen Guangdong Province, Shenzhen City, Guangdong Province, 518102ICU, Bao’an Central Hospital of Shenzhen Guangdong Province, Shenzhen City, Guangdong Province, 518102Emergency Medicine Department, Bao’an Central Hospital of Shenzhen Guangdong Province, Shenzhen City, Guangdong Province, 518102Objective: To study the correlation between shock index and inflammation, oxidative stress as well as target organ damage in patients with sepsis. Methods: A total of 70 patients with sepsis treated in our hospital between March 2013 and May 2016 were collected and divided into no shock group (SI<0.5) (n=11), general shock group (0.5≤SI≤2) (n=42) and severe shock group (SI>2.0) (n=17) according to the shock index (SI). Immediately after admission, serum levels of inflammatory factors, oxidative stress indexes and liver function indexes were detected. Results: Serum interleukin-1β (IL-1β), interleukin-8 (IL-8), tumor necrosis factor α (TNF-α), advanced oxidation protein products (AOPPs), total bilirubin (TB), γ-glutamyl transpeptidase (GGT) and alanine aminotransferase (ALT) levels of severe shock group and general shock group were higher than those of no shock group while anti-inflammatory factors interleukin-10 (IL-10), interleukin-13 (IL-13), soluble tumor necrosis factor receptor Ⅰ (sTNF-RI), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) and catalase (CAT) levels were lower than those of no shock group; serum IL-1β, IL-8, TNF-α, AOPPs, TB, GGT and ALT levels of severe shock group were higher than those of general shock group while IL-10, IL-13, sTNF-RI, CAT, GSH-Px and SOD levels were lower than those of general shock group. Conclusion: The higher the shock index in patients with sepsis, the more severe the inflammation, oxidative stress and target organ damage, and the two are positively correlated.http://www.hnykdxxb.com/PDF/201704/9.pdfSepsisShock indexInflammationOxidative stressTarget organ damage |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei-Zhou Zhong Qing-Shan Liu Yuan-Tong Ou Fu-Gang Gao |
spellingShingle |
Wei-Zhou Zhong Qing-Shan Liu Yuan-Tong Ou Fu-Gang Gao Correlation between shock index and inflammation, oxidative stress as well as target organ damage in patients with sepsis Journal of Hainan Medical University Sepsis Shock index Inflammation Oxidative stress Target organ damage |
author_facet |
Wei-Zhou Zhong Qing-Shan Liu Yuan-Tong Ou Fu-Gang Gao |
author_sort |
Wei-Zhou Zhong |
title |
Correlation between shock index and inflammation, oxidative stress as well as target organ damage in patients with sepsis |
title_short |
Correlation between shock index and inflammation, oxidative stress as well as target organ damage in patients with sepsis |
title_full |
Correlation between shock index and inflammation, oxidative stress as well as target organ damage in patients with sepsis |
title_fullStr |
Correlation between shock index and inflammation, oxidative stress as well as target organ damage in patients with sepsis |
title_full_unstemmed |
Correlation between shock index and inflammation, oxidative stress as well as target organ damage in patients with sepsis |
title_sort |
correlation between shock index and inflammation, oxidative stress as well as target organ damage in patients with sepsis |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 |
publishDate |
2017-04-01 |
description |
Objective: To study the correlation between shock index and inflammation, oxidative stress
as well as target organ damage in patients with sepsis. Methods: A total of 70 patients with
sepsis treated in our hospital between March 2013 and May 2016 were collected and divided
into no shock group (SI<0.5) (n=11), general shock group (0.5≤SI≤2) (n=42) and severe shock
group (SI>2.0) (n=17) according to the shock index (SI). Immediately after admission, serum
levels of inflammatory factors, oxidative stress indexes and liver function indexes were
detected. Results: Serum interleukin-1β (IL-1β), interleukin-8 (IL-8), tumor necrosis factor
α (TNF-α), advanced oxidation protein products (AOPPs), total bilirubin (TB), γ-glutamyl
transpeptidase (GGT) and alanine aminotransferase (ALT) levels of severe shock group and
general shock group were higher than those of no shock group while anti-inflammatory factors
interleukin-10 (IL-10), interleukin-13 (IL-13), soluble tumor necrosis factor receptor Ⅰ
(sTNF-RI), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) and catalase
(CAT) levels were lower than those of no shock group; serum IL-1β, IL-8, TNF-α, AOPPs,
TB, GGT and ALT levels of severe shock group were higher than those of general shock
group while IL-10, IL-13, sTNF-RI, CAT, GSH-Px and SOD levels were lower than those of
general shock group. Conclusion: The higher the shock index in patients with sepsis, the more
severe the inflammation, oxidative stress and target organ damage, and the two are positively
correlated. |
topic |
Sepsis Shock index Inflammation Oxidative stress Target organ damage |
url |
http://www.hnykdxxb.com/PDF/201704/9.pdf |
work_keys_str_mv |
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