Clinical outcomes of patients undergoing percutaneous left atrial appendage occlusion in general anaesthesia or conscious sedation: data from the prospective global Amplatzer Amulet Occluder Observational Study
Objective To evaluate the safety and efficacy of percutaneous left atrial appendage occlusion (LAAO) using conscious sedation (CS).Background Several percutaneous structural heart disease interventions are safely and efficiently performed using CS instead of general anaesthesia (GA). This concept ha...
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doaj-bf4b85d2ec28401cbc495d46294c601a2021-07-02T13:09:16ZengBMJ Publishing GroupBMJ Open2044-60552021-03-0111310.1136/bmjopen-2020-040455Clinical outcomes of patients undergoing percutaneous left atrial appendage occlusion in general anaesthesia or conscious sedation: data from the prospective global Amplatzer Amulet Occluder Observational StudyMatteo Montorfano0Kerstin Piayda1Katharina Hellhammer2Sergio Berti3Jens Erik Nielsen-Kudsk4Boris Schmidt5Patrizio Mazzone6Sven Fischer7Juha Lund8Paolo Della Bella9Ryan Gage10Tobias Zeus11Department of Interventional Cardiology, Istituto Scientifico Universitario San Raffaele, Milano, Lombardia, ItalyDepartment of Cardiology, Pneumology and Vascular Medicine, Heinrich Heine University Düsseldorf, Duesseldorf, Nordrhein-Westfalen, GermanyDepartment of Cardiology, Pneumology and Vascular Medicine, Heinrich Heine University Düsseldorf, Duesseldorf, Nordrhein-Westfalen, GermanyDepartment of Cardiology, Fondazione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanita Pubblica, Pisa, Toscana, ItalyDepartment of Cardiology, Aarhus University, Aarhus, DenmarkDepartment of Cardiology, Bethanien-Krankenhaus, Frankfurt am Main, Hessen, GermanyDepartment of Cardiology, Ospedale San Raffaele, Milano, ItalyDepartment of Cardiology, Harzklinikum Dorothea Christiane Erxleben GmbH, Quedlinburg, Sachsen-Anhalt, GermanyDepartment of Cardiology, Turku University Hospital, Turku, FinlandDepartment of Arrhythmology, San Raffaele Hospital, Milano, Lombardia, ItalyStructural Heart, Abbott Cardiovascular—St Paul, Saint Paul, Minnesota, USADepartment of Cardiology, Pneumology and Vascular Medicine, Heinrich Heine University Düsseldorf, Duesseldorf, Nordrhein-Westfalen, GermanyObjective To evaluate the safety and efficacy of percutaneous left atrial appendage occlusion (LAAO) using conscious sedation (CS).Background Several percutaneous structural heart disease interventions are safely and efficiently performed using CS instead of general anaesthesia (GA). This concept has not been evaluated in a large multicenter cohort of patients undergoing LAAO.Methods Patients from the prospective, global Amplatzer Amulet Occluder Observational Study were divided into two groups (GA vs CS). Baseline information, periprocedural and postprocedural efficacy and complications, as well as outcomes through 7 days post implant were compared.Results Patients undergoing transesophageal-guided implants were categorised by GA (n=607, 64%) or CS (n=342, 36%) usage. Mean age was 75 years in both groups. LAAO technical success was achieved in 99% of both groups. The procedure duration (GA: 35±22 min vs CS: 27±19 min, p<0.001), total amount of contrast medium (GA: 105±81 mL vs CS: 86±66 mL, p<0.001) and fluoroscopic time (GA: 13±9 min vs CS: 12±13 min, p<0.001) were less in CS cases. Procedure-related or device-related serious adverse events during the first 7 days were numerically higher in the CS group (GA: 4.9% vs CS: 7.6%, p=0.114). Peridevice residual flow was absent or ≤5 mm 1–3 months after the procedure in 99.7% of the GA and in 100% of the CS group (p=1.000).Conclusions In a large global study, LAAO with the Amplatzer Amulet occluder is safe and feasible using CS. Procedure duration and total amount of contrast were less with CS than GA cases.Trial registration number NCT02447081; Results.https://bmjopen.bmj.com/content/11/3/e040455.full |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Matteo Montorfano Kerstin Piayda Katharina Hellhammer Sergio Berti Jens Erik Nielsen-Kudsk Boris Schmidt Patrizio Mazzone Sven Fischer Juha Lund Paolo Della Bella Ryan Gage Tobias Zeus |
spellingShingle |
Matteo Montorfano Kerstin Piayda Katharina Hellhammer Sergio Berti Jens Erik Nielsen-Kudsk Boris Schmidt Patrizio Mazzone Sven Fischer Juha Lund Paolo Della Bella Ryan Gage Tobias Zeus Clinical outcomes of patients undergoing percutaneous left atrial appendage occlusion in general anaesthesia or conscious sedation: data from the prospective global Amplatzer Amulet Occluder Observational Study BMJ Open |
author_facet |
Matteo Montorfano Kerstin Piayda Katharina Hellhammer Sergio Berti Jens Erik Nielsen-Kudsk Boris Schmidt Patrizio Mazzone Sven Fischer Juha Lund Paolo Della Bella Ryan Gage Tobias Zeus |
author_sort |
Matteo Montorfano |
title |
Clinical outcomes of patients undergoing percutaneous left atrial appendage occlusion in general anaesthesia or conscious sedation: data from the prospective global Amplatzer Amulet Occluder Observational Study |
title_short |
Clinical outcomes of patients undergoing percutaneous left atrial appendage occlusion in general anaesthesia or conscious sedation: data from the prospective global Amplatzer Amulet Occluder Observational Study |
title_full |
Clinical outcomes of patients undergoing percutaneous left atrial appendage occlusion in general anaesthesia or conscious sedation: data from the prospective global Amplatzer Amulet Occluder Observational Study |
title_fullStr |
Clinical outcomes of patients undergoing percutaneous left atrial appendage occlusion in general anaesthesia or conscious sedation: data from the prospective global Amplatzer Amulet Occluder Observational Study |
title_full_unstemmed |
Clinical outcomes of patients undergoing percutaneous left atrial appendage occlusion in general anaesthesia or conscious sedation: data from the prospective global Amplatzer Amulet Occluder Observational Study |
title_sort |
clinical outcomes of patients undergoing percutaneous left atrial appendage occlusion in general anaesthesia or conscious sedation: data from the prospective global amplatzer amulet occluder observational study |
publisher |
BMJ Publishing Group |
series |
BMJ Open |
issn |
2044-6055 |
publishDate |
2021-03-01 |
description |
Objective To evaluate the safety and efficacy of percutaneous left atrial appendage occlusion (LAAO) using conscious sedation (CS).Background Several percutaneous structural heart disease interventions are safely and efficiently performed using CS instead of general anaesthesia (GA). This concept has not been evaluated in a large multicenter cohort of patients undergoing LAAO.Methods Patients from the prospective, global Amplatzer Amulet Occluder Observational Study were divided into two groups (GA vs CS). Baseline information, periprocedural and postprocedural efficacy and complications, as well as outcomes through 7 days post implant were compared.Results Patients undergoing transesophageal-guided implants were categorised by GA (n=607, 64%) or CS (n=342, 36%) usage. Mean age was 75 years in both groups. LAAO technical success was achieved in 99% of both groups. The procedure duration (GA: 35±22 min vs CS: 27±19 min, p<0.001), total amount of contrast medium (GA: 105±81 mL vs CS: 86±66 mL, p<0.001) and fluoroscopic time (GA: 13±9 min vs CS: 12±13 min, p<0.001) were less in CS cases. Procedure-related or device-related serious adverse events during the first 7 days were numerically higher in the CS group (GA: 4.9% vs CS: 7.6%, p=0.114). Peridevice residual flow was absent or ≤5 mm 1–3 months after the procedure in 99.7% of the GA and in 100% of the CS group (p=1.000).Conclusions In a large global study, LAAO with the Amplatzer Amulet occluder is safe and feasible using CS. Procedure duration and total amount of contrast were less with CS than GA cases.Trial registration number NCT02447081; Results. |
url |
https://bmjopen.bmj.com/content/11/3/e040455.full |
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