Preparation of parenteral nanocrystal suspensions of etoposide from the excipient free dry state of the drug to enhance in vivo antitumoral properties
Abstract Nanoparticle technology in cancer chemotherapy is a promising approach to enhance active ingredient pharmacology and pharmacodynamics. Indeed, drug nanoparticles display various assets such as extended blood lifespan, high drug loading and reduced cytotoxicity leading to better drug complia...
Main Authors: | Brice Martin, Johanne Seguin, Maxime Annereau, Thomas Fleury, René Lai-Kuen, Giovanni Neri, Anita Lam, Marcel Bally, Nathalie Mignet, Yohann Corvis |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-10-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-74809-z |
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