Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening
Abstract Fecal immunochemical test (FIT) is widely used as a colorectal cancer screening tool. Antithrombotic drugs may affect the screening performance of FIT for colorectal tumors. The aim of this study was to clarify the effect of antithrombotic agents on FIT accuracy in screening for colorectal...
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2021-02-01
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doaj-bf5916ec0aaa4ae3a67943561778b7232021-02-23T10:36:06ZengNature Publishing GroupScientific Reports2045-23222021-02-011111710.1038/s41598-021-83007-4Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screeningTakashi Ibuka0Seiji Adachi1Yohei Horibe2Tomohiko Ohno3Masatoshi Mabuchi4Yusuke Suzuki5Osamu Yamauchi6Eri Takada7Midori Iwama8Koshiro Saito9Masamichi Arao10Koji Takai11Hiroshi Araki12Masahito Shimizu13Division for Regional Cancer Control, Gifu University Graduate School of MedicineDepartment of Gastroenterology/Internal Medicine, Gihoku Kosei HospitalDepartment of Gastroenterology/Internal Medicine, Gihoku Kosei HospitalDepartment of Gastroenterology/Internal Medicine, Gihoku Kosei HospitalDepartment of Gastroenterology/Internal Medicine, Gihoku Kosei HospitalDepartment of Gastroenterology/Internal Medicine, Gihoku Kosei HospitalDepartment of Gastroenterology/Internal Medicine, Gihoku Kosei HospitalDepartment of Gastroenterology/Internal Medicine, Gihoku Kosei HospitalDepartment of Gastroenterology/Internal Medicine, Gihoku Kosei HospitalDepartment of Gastroenterology/Internal Medicine, Gihoku Kosei HospitalDepartment of Gastroenterology, Gifu University Graduate School of MedicineDivision for Regional Cancer Control, Gifu University Graduate School of MedicineDepartment of Gastroenterology, Gifu University Graduate School of MedicineDepartment of Gastroenterology, Gifu University Graduate School of MedicineAbstract Fecal immunochemical test (FIT) is widely used as a colorectal cancer screening tool. Antithrombotic drugs may affect the screening performance of FIT for colorectal tumors. The aim of this study was to clarify the effect of antithrombotic agents on FIT accuracy in screening for colorectal neoplasms. This retrospective study enrolled a total of 758 patients who underwent both FIT and total colonoscopy. The effect of antithrombotic drugs on FIT accuracy in detecting colorectal neoplasms (CN), including colorectal cancer (CRC), advanced adenoma (AA), and non-advanced adenoma (NAA), was examined. Of the 758 patients, 144 (19%) received antithrombotic drugs (administration group). In administration group, 61/144 (42%) cases had CN [CRC:14, AA:15, NAA:32] and 217/614 (35%) cases had CN (CRC:43, AA:56, NAA:118) in non-administration group. The prevalence of CN was not significantly different between the two groups (p = 0.1157). There was no significant difference in sensitivity or specificity of the detection of all types of CN with or without taking antithrombotic drugs. Neither the positive predictive value nor negative predictive value of FIT was affected by antithrombotic drug administration. Taking antithrombotic drugs may not have a large impact on sensitivity, specificity, positive predictive value, or negative predictive value of FIT in screening for CN.https://doi.org/10.1038/s41598-021-83007-4 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Takashi Ibuka Seiji Adachi Yohei Horibe Tomohiko Ohno Masatoshi Mabuchi Yusuke Suzuki Osamu Yamauchi Eri Takada Midori Iwama Koshiro Saito Masamichi Arao Koji Takai Hiroshi Araki Masahito Shimizu |
spellingShingle |
Takashi Ibuka Seiji Adachi Yohei Horibe Tomohiko Ohno Masatoshi Mabuchi Yusuke Suzuki Osamu Yamauchi Eri Takada Midori Iwama Koshiro Saito Masamichi Arao Koji Takai Hiroshi Araki Masahito Shimizu Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening Scientific Reports |
author_facet |
Takashi Ibuka Seiji Adachi Yohei Horibe Tomohiko Ohno Masatoshi Mabuchi Yusuke Suzuki Osamu Yamauchi Eri Takada Midori Iwama Koshiro Saito Masamichi Arao Koji Takai Hiroshi Araki Masahito Shimizu |
author_sort |
Takashi Ibuka |
title |
Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening |
title_short |
Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening |
title_full |
Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening |
title_fullStr |
Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening |
title_full_unstemmed |
Effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening |
title_sort |
effects of antithrombotic drugs on the results of fecal immunochemical test in colorectal neoplasms screening |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-02-01 |
description |
Abstract Fecal immunochemical test (FIT) is widely used as a colorectal cancer screening tool. Antithrombotic drugs may affect the screening performance of FIT for colorectal tumors. The aim of this study was to clarify the effect of antithrombotic agents on FIT accuracy in screening for colorectal neoplasms. This retrospective study enrolled a total of 758 patients who underwent both FIT and total colonoscopy. The effect of antithrombotic drugs on FIT accuracy in detecting colorectal neoplasms (CN), including colorectal cancer (CRC), advanced adenoma (AA), and non-advanced adenoma (NAA), was examined. Of the 758 patients, 144 (19%) received antithrombotic drugs (administration group). In administration group, 61/144 (42%) cases had CN [CRC:14, AA:15, NAA:32] and 217/614 (35%) cases had CN (CRC:43, AA:56, NAA:118) in non-administration group. The prevalence of CN was not significantly different between the two groups (p = 0.1157). There was no significant difference in sensitivity or specificity of the detection of all types of CN with or without taking antithrombotic drugs. Neither the positive predictive value nor negative predictive value of FIT was affected by antithrombotic drug administration. Taking antithrombotic drugs may not have a large impact on sensitivity, specificity, positive predictive value, or negative predictive value of FIT in screening for CN. |
url |
https://doi.org/10.1038/s41598-021-83007-4 |
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