Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study
Lead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antio...
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doaj-bf5b2472bddb42a9b0cfe99da2130a512020-11-24T23:55:23ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/856319856319Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT StudyJintana Sirivarasai0Sukhumpun Kaojarern1Suwannee Chanprasertyothin2Pachara Panpunuan3Krittaya Petchpoung4Aninthita Tatsaneeyapant5Krongtong Yoovathaworn6Thunyachai Sura7Sming Kaojarern8Piyamit Sritara9Graduate Program in Nutrition, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandCardiovascular and Metabolic Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandOffice of Research Academic and Innovation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandResearch and Development Institute, Kasetsart University, Bangkok 10900, ThailandHealth Office, Electricity Generating Authority of Thailand, Nonthaburi 11130, ThailandDepartment of Pharmacology, Faculty of Science, Mahidol University, Bangkok 10400, ThailandDepartment of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandOccupational and Environmental Toxicology Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandDepartment of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, ThailandLead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxidative stress-marker (malondialdehyde), and blood lead level and (2) the influence of genetic polymorphism of CAT gene (rs769217) on change in blood pressure in general population of EGAT study project. This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects. Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P<0.05). These significant findings are also found in MDA levels. Moreover, individuals with TT genotype in hypertensive group had significantly higher blood lead and MDA levels (6.06 μg/dL and 9.67 μmol/L) than those with CC genotype (5.32 μg/dL and 8.31 μmol/L, P<0.05). Our findings suggested that decreased blood catalase activity in this polymorphism together with low level lead exposure induced lipid peroxidation may be responsible for hypertension.http://dx.doi.org/10.1155/2015/856319 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jintana Sirivarasai Sukhumpun Kaojarern Suwannee Chanprasertyothin Pachara Panpunuan Krittaya Petchpoung Aninthita Tatsaneeyapant Krongtong Yoovathaworn Thunyachai Sura Sming Kaojarern Piyamit Sritara |
spellingShingle |
Jintana Sirivarasai Sukhumpun Kaojarern Suwannee Chanprasertyothin Pachara Panpunuan Krittaya Petchpoung Aninthita Tatsaneeyapant Krongtong Yoovathaworn Thunyachai Sura Sming Kaojarern Piyamit Sritara Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study BioMed Research International |
author_facet |
Jintana Sirivarasai Sukhumpun Kaojarern Suwannee Chanprasertyothin Pachara Panpunuan Krittaya Petchpoung Aninthita Tatsaneeyapant Krongtong Yoovathaworn Thunyachai Sura Sming Kaojarern Piyamit Sritara |
author_sort |
Jintana Sirivarasai |
title |
Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study |
title_short |
Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study |
title_full |
Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study |
title_fullStr |
Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study |
title_full_unstemmed |
Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study |
title_sort |
environmental lead exposure, catalase gene, and markers of antioxidant and oxidative stress relation to hypertension: an analysis based on the egat study |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
Lead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxidative stress-marker (malondialdehyde), and blood lead level and (2) the influence of genetic polymorphism of CAT gene (rs769217) on change in blood pressure in general population of EGAT study project. This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects. Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P<0.05). These significant findings are also found in MDA levels. Moreover, individuals with TT genotype in hypertensive group had significantly higher blood lead and MDA levels (6.06 μg/dL and 9.67 μmol/L) than those with CC genotype (5.32 μg/dL and 8.31 μmol/L, P<0.05). Our findings suggested that decreased blood catalase activity in this polymorphism together with low level lead exposure induced lipid peroxidation may be responsible for hypertension. |
url |
http://dx.doi.org/10.1155/2015/856319 |
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