Toward a Macaque Model of HIV-1 Infection: Roadblocks, Progress, and Future Strategies

Toward a Macaque Model of HIV-1 Infection: Roadblocks, Progress, and Future Strategies

The human-specific tropism of Human Immunodeficiency Virus Type 1 (HIV-1) has complicated the development of a macaque model of HIV-1 infection/AIDS that is suitable for preclinical evaluation of vaccines and novel treatment strategies. Several innate retroviral restriction factors, such as APOBEC3...

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Bibliographic Details
Main Authors: Rajesh Thippeshappa, Jason T. Kimata, Deepak Kaushal
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Microbiology
Subjects:
HIV-1
HSIV
stHIV
macaque model
pigtailed macaques
interferon
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00882/full

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