Full-length mRNA sequencing uncovers a widespread coupling between transcription initiation and mRNA processing
Abstract Background The multifaceted control of gene expression requires tight coordination of regulatory mechanisms at transcriptional and post-transcriptional level. Here, we studied the interdependence of transcription initiation, splicing and polyadenylation events on single mRNA molecules by fu...
Main Authors: | , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2018-03-01
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Series: | Genome Biology |
Online Access: | http://link.springer.com/article/10.1186/s13059-018-1418-0 |