Sonic Hedgehog Is a Member of the Hh/DD-Peptidase Family That Spans the Eukaryotic and Bacterial Domains of Life
Sonic Hedgehog (Shh) coordinates Zn2+ in a manner that resembles that of peptidases. The ability of Shh to undergo autoproteolytic processing is impaired in mutants that affect the Zn2+ coordination, while mutating residues essential for catalytic activity results in more stable forms of Shh. The re...
Main Author: | Henk Roelink |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-06-01
|
Series: | Journal of Developmental Biology |
Subjects: | |
Online Access: | http://www.mdpi.com/2221-3759/6/2/12 |
Similar Items
-
C-Terminal Peptide Modifications Reveal Direct and Indirect Roles of Hedgehog Morphogen Cholesteroylation
by: Dominique Manikowski, et al.
Published: (2021-01-01) -
Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease
by: Marilyn D. Resh
Published: (2021-03-01) -
Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells following transfection with Indian hedgehog and sonic hedgehog using a rotary cell culture system
by: Liyang Chen, et al.
Published: (2019-02-01) -
Sonic hedgehog expression in the postnatal brain
by: Aileen Rivell, et al.
Published: (2019-03-01) -
The Binding Mode of the Sonic Hedgehog Inhibitor Robotnikinin, a Combined Docking and QM/MM MD Study
by: Manuel Hitzenberger, et al.
Published: (2017-10-01)