First encounter of subclinical human Leishmania (Viannia) infection in State of Rio Grande do Sul, Brazil
The objective of the present study was to evaluate the specificity of the Montenegro skin test (MST) in an area in Brazil, state of Grande do Sul State (RS), which was considered to be non-endemic for leishmaniasis. Sixty subjects presented a positive MST and were reevaluated by clinical examination...
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Instituto Oswaldo Cruz, Ministério da Saúde
2007-12-01
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doaj-bf6d5248d30049d69f79a8891ac4a52e2020-11-24T21:09:30ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.0074-02761678-80602007-12-0110281003100510.1590/S0074-02762007000800018First encounter of subclinical human Leishmania (Viannia) infection in State of Rio Grande do Sul, BrazilAline FagundesMauro CA MarzochiOctavio FernandesMauricio A PerezArmando O SchubachTânia MP SchubachMaria RR AmendoeiraEliame Mouta-ConfortKeyla BF MarzochiThe objective of the present study was to evaluate the specificity of the Montenegro skin test (MST) in an area in Brazil, state of Grande do Sul State (RS), which was considered to be non-endemic for leishmaniasis. Sixty subjects presented a positive MST and were reevaluated by clinical examination, serology and polymerase chain reaction (PCR) of peripheral blood for the detection of subclinical Leishmania infection. None of the subjects presented clinical signs or symptoms of current leishmaniasis or a history of the disease.Leishmania (Viannia) DNA was detected in blood by PCR and hybridization in one subject. The PCR skin test-positive individual remained asymptomatic throughout the study. Clinical examination showed no scars suggestive of past cutaneous leishmaniasis. Human subclinical infection with Leishmania (Viannia) in RS was confirmed by PCR. This is the first report of subclinical infection with this parasite in the human population of this area.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000800018LeishmaniaPCRMontenegro skin testsubclinical infectionRio Grande do SulBrazil |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aline Fagundes Mauro CA Marzochi Octavio Fernandes Mauricio A Perez Armando O Schubach Tânia MP Schubach Maria RR Amendoeira Eliame Mouta-Confort Keyla BF Marzochi |
spellingShingle |
Aline Fagundes Mauro CA Marzochi Octavio Fernandes Mauricio A Perez Armando O Schubach Tânia MP Schubach Maria RR Amendoeira Eliame Mouta-Confort Keyla BF Marzochi First encounter of subclinical human Leishmania (Viannia) infection in State of Rio Grande do Sul, Brazil Memórias do Instituto Oswaldo Cruz. Leishmania PCR Montenegro skin test subclinical infection Rio Grande do Sul Brazil |
author_facet |
Aline Fagundes Mauro CA Marzochi Octavio Fernandes Mauricio A Perez Armando O Schubach Tânia MP Schubach Maria RR Amendoeira Eliame Mouta-Confort Keyla BF Marzochi |
author_sort |
Aline Fagundes |
title |
First encounter of subclinical human Leishmania (Viannia) infection in State of Rio Grande do Sul, Brazil |
title_short |
First encounter of subclinical human Leishmania (Viannia) infection in State of Rio Grande do Sul, Brazil |
title_full |
First encounter of subclinical human Leishmania (Viannia) infection in State of Rio Grande do Sul, Brazil |
title_fullStr |
First encounter of subclinical human Leishmania (Viannia) infection in State of Rio Grande do Sul, Brazil |
title_full_unstemmed |
First encounter of subclinical human Leishmania (Viannia) infection in State of Rio Grande do Sul, Brazil |
title_sort |
first encounter of subclinical human leishmania (viannia) infection in state of rio grande do sul, brazil |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
series |
Memórias do Instituto Oswaldo Cruz. |
issn |
0074-0276 1678-8060 |
publishDate |
2007-12-01 |
description |
The objective of the present study was to evaluate the specificity of the Montenegro skin test (MST) in an area in Brazil, state of Grande do Sul State (RS), which was considered to be non-endemic for leishmaniasis. Sixty subjects presented a positive MST and were reevaluated by clinical examination, serology and polymerase chain reaction (PCR) of peripheral blood for the detection of subclinical Leishmania infection. None of the subjects presented clinical signs or symptoms of current leishmaniasis or a history of the disease.Leishmania (Viannia) DNA was detected in blood by PCR and hybridization in one subject. The PCR skin test-positive individual remained asymptomatic throughout the study. Clinical examination showed no scars suggestive of past cutaneous leishmaniasis. Human subclinical infection with Leishmania (Viannia) in RS was confirmed by PCR. This is the first report of subclinical infection with this parasite in the human population of this area. |
topic |
Leishmania PCR Montenegro skin test subclinical infection Rio Grande do Sul Brazil |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000800018 |
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