Juvenile Granulosa Cell Tumor of the Testicle – Report of a Neonatal Case with Positive Alpha-fetoprotein Immunohistochemical Staining

• Main Authors: Melissa Dundas, Mark Horowitz, Richard Sidlow
• Format: Article
• Language: English
• Published: Elsevier 2017-05-01
• Series: Urology Case Reports
• Subjects: Juvenile granulosa cell tumor; Testicle; Neonate; Alpha fetoprotein; Immunohistochemistry
• Online Access: http://www.sciencedirect.com/science/article/pii/S2214442017300177

We report on a case of juvenile granulosa cell tumor of the testicle in a neonate, a rare testicular tumor in children. No genital ambiguity, anatomic abnormalities, nor sex chromosome aneuploidy was noted in this patient. In our case, despite positive staining for alpha-fetoprotein which is most consistent with yolk sac tumors, all clinical, gross anatomic, histologic, and other immunohistologic characteristics of the tumor remained consistent with the diagnosis of juvenile granulosa cell tumor. The alpha-fetoprotein positivity of the tumor remains unexplained.