Enabling Efficient Folding and High-Resolution Crystallographic Analysis of Bracelet Cyclotides

Enabling Efficient Folding and High-Resolution Crystallographic Analysis of Bracelet Cyclotides

Cyclotides have attracted great interest as drug design scaffolds because of their unique cyclic cystine knotted topology. They are classified into three subfamilies, among which the bracelet subfamily represents the majority and comprises the most bioactive cyclotides, but are the most poorly utili...

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Bibliographic Details
Main Authors: Yen-Hua Huang, Qingdan Du, Zhihao Jiang, Gordon J. King, Brett M. Collins, Conan K. Wang, David J. Craik
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
peptides
crystal structures
cyclic peptides
cyclotides
quasi-racemic crystallography
Online Access:https://www.mdpi.com/1420-3049/26/18/5554

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