A spiroligomer α-helix mimic that binds HDM2, penetrates human cells and stabilizes HDM2 in cell culture.
We demonstrate functionalized spiroligomers that mimic the HDM2-bound conformation of the p53 activation domain. Spiroligomers are stereochemically defined, functionalized, spirocyclic monomers coupled through pairs of amide bonds to create spiro-ladder oligomers. Two series of spiroligomers were sy...
Main Authors: | Zachary Z Brown, Kavitha Akula, Alla Arzumanyan, Jennifer Alleva, Marcus Jackson, Eugeney Bichenkov, Joel B Sheffield, Mark A Feitelson, Christian E Schafmeister |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3475717?pdf=render |
Similar Items
-
The C2HDM revisited
by: Duarte Fontes, et al.
Published: (2018-02-01) -
Characterization of HDM2 domains
by: Yu, Grace Wang
Published: (2006) -
Vacuum instabilities in the N2HDM
by: P. M. Ferreira, et al.
Published: (2019-09-01) -
The dark phases of the N2HDM
by: Isabell Engeln, et al.
Published: (2020-08-01) -
Higher dimensional operators in 2HDM
by: Siddhartha Karmakar, et al.
Published: (2017-10-01)