Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial

Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial

Background: Type 2 diabetes patients and individuals at risk of developing diabetes are characterized by metabolic inflexibility and disturbed glucose homeostasis. Low carnitine availability may contribute to metabolic inflexibility and impaired glucose tolerance. Here, we investigated whether carni...

Full description

Bibliographic Details
Main Authors:	Yvonne MH Bruls, Marlies de Ligt, Lucas Lindeboom, Esther Phielix, Bas Havekes, Gert Schaart, Esther Kornips, Joachim E Wildberger, Matthijs KC Hesselink, Deborah Muoio, Patrick Schrauwen, Vera B Schrauwen-Hinderling
Format:	Article
Language:	English
Published:	Elsevier 2019-11-01
Series:	EBioMedicine
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396419306802

Similar Items

L-carnitine infusion does not alleviate lipid-induced insulin resistance and metabolic inflexibility.
by: Yvonne M H Bruls, et al.
Published: (2020-01-01)

Resveratrol improves ex vivo mitochondrial function but does not affect insulin sensitivity or brown adipose tissue in first degree relatives of patients with type 2 diabetes
by: Marlies de Ligt, et al.
Published: (2018-06-01)

Resveratrol‐induced remodelling of myocellular lipid stores: A study in metabolically compromised humans
by: Nynke vanPolanen, et al.
Published: (2021-01-01)

Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia
by: Giancarlo Balercia, et al.
Published: (2014-12-01)

Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia
by: Giancarlo Balercia, et al.
Published: (2014-12-01)

Relationship of C5L2 receptor to skeletal muscle substrate utilization.
by: Christian Roy, et al.
Published: (2013-01-01)

Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia
by: Cecilia Maldonado, et al.
Published: (2016-01-01)

Metabolic responses to mild cold acclimation in type 2 diabetes patients
by: Carlijn M. E. Remie, et al.
Published: (2021-03-01)

Evaluation of Muscle microRNA Expression in Relation to Human Peripheral Insulin Sensitivity: A Cross-Sectional Study in Metabolically Distinct Subject Groups
by: Dennis Dahlmans, et al.
Published: (2017-09-01)

Relationships between mitochondrial function and metabolic flexibility in type 2 diabetes mellitus.
by: Tineke van de Weijer, et al.
Published: (2013-01-01)

DGAT1 overexpression in muscle by in vivo DNA electroporation increases intramyocellular lipid content
by: Berber D. Roorda, et al.
Published: (2005-02-01)

Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete's paradox
by: Sabine Daemen, et al.
Published: (2018-11-01)

THE CRYSTAL STRUCTURE OF ACETYLCARNITINE-CHLORIDE
by: WERNESS, PETER GARDNER
Published: (2007)

Prevention of high-fat diet-induced muscular lipid accumulation in rats by α lipoic acid is not mediated by AMPK activation[S]
by: Silvie Timmers, et al.
Published: (2010-02-01)

Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
by: Kay H. M. Roumans, et al.
Published: (2020-04-01)

Cardiac lipid content is unresponsive to a physical activity training intervention in type 2 diabetic patients, despite improved ejection fraction
by: Leiner Tim, et al.
Published: (2011-05-01)

Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals
by: Jakob Wefers, et al.
Published: (2020-11-01)

Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity
by: Dirk van Moorsel, et al.
Published: (2016-08-01)

Towards the Design of Carnitine Acyltransferase Inhibitors: Modeling the Conformational Behavior of (<em>R</em>)-Carnitine, (<em>R</em>)-Acetylcarnitine, Morpholinium rings, and 2-Oxo-1,3,6-dioxazaphosphacinium rings
by: Rosas-Garcia, Victor Manuel
Published: (2017)

Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function
by: L. Grevendonk, et al.
Published: (2021-08-01)

Poor Efficacy of L-Acetylcarnitine in the Treatment of Asthenozoospermia in Patients with Type 1 Diabetes
by: Rosita A. Condorelli, et al.
Published: (2019-04-01)

l-Acetylcarnitine: A Mechanistically Distinctive and Potentially Rapid-Acting Antidepressant Drug
by: Santina Chiechio, et al.
Published: (2017-12-01)

PPARγ coactivator-1α contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans
by: Timothy R. Koves, et al.
Published: (2013-02-01)

(Not) losing out from Brexit *
by: Annette Schrauwen
Published: (2017-05-01)

Transplacental exposure to AZT induces adverse neurochemical and behavioral effects in a mouse model: protection by L-acetylcarnitine.
by: Anna Rita Zuena, et al.
Published: (2013-01-01)

L-Acetylcarnitine in dysthymic disorder in elderly patients: a double-blind, multicenter, controlled randomized study vs. fluoxetine
by: Giuseppe Bersania, et al.
Published: (2015-02-01)

Correction: Transplacental Exposure to AZT Induces Adverse Neurochemical and Behavioral Effects in a Mouse Model: Protection by L-Acetylcarnitine
by: Anna Rita Zuena, et al.
Published: (2013-01-01)

Correction: Transplacental Exposure to AZT Induces Adverse Neurochemical and Behavioral Effects in a Mouse Model: Protection by L-Acetylcarnitine.
by: Anna Rita Zuena, et al.
Published: (2013-01-01)

Carnitine and carnitine acetyltransferase; their role in development
by: Seccombe, David William
Published: (2010)

<i>N</i>-acetyltaurine and Acetylcarnitine Production for the Mitochondrial Acetyl-CoA Regulation in Skeletal Muscles during Endurance Exercises
by: Teruo Miyazaki, et al.
Published: (2021-08-01)

Resveratrol supplementation reduces ACE2 expression in human adipose tissue
by: Marlies de Ligt, et al.
Published: (2021-01-01)

Comparative transcriptome analysis of human skeletal muscle in response to cold acclimation and exercise training in human volunteers
by: Emmani B. M. Nascimento, et al.
Published: (2020-09-01)

Obesity and lipid stress inhibit carnitine acetyltransferase activity[S]
by: Sarah E. Seiler, et al.
Published: (2014-04-01)

Carnitine acyltransferases
by: Edwards, M. R.
Published: (1973)

Urinary excretion of L-carnitine, acetyl-L-carnitine, propionyl-L-carnitine and their antioxidant activities after single dose administration of L-carnitine in healthy subjects
by: Yu Cao, et al.
Published: (2013-03-01)

Prevalence of Carnitine Deficiency and Decreased Carnitine Levels in Patients on Peritoneal Dialysis
by: Satoshi Shimizu, et al.
Published: (2019-11-01)

The carnitine and carnitine ester content of rat bile and human duodenal fluid
by: Hamilton, Jennifer Jane
Published: (2010)

Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle.
by: Silvie Timmers, et al.
Published: (2011-01-01)

Carnitine Deficiency Syndromes
by: J Gordon Millichap
Published: (1996-01-01)

Carnitine analysis in pterygium
by: Ayhan Saglik, et al.

Cannot write session to /tmp/vufind_sessions/sess_0kj9hmbv1isng4i3t1014sjgmq