Amyloid-Beta Influences Memory via Functional Connectivity During Memory Retrieval in Alzheimer's Disease
Objective: Amnesia in Alzheimer's disease (AD) appears early and could be caused by encoding deficiency, consolidation dysfunction, and/or impairment in the retrieval of stored memory information. The relationship between AD pathology biomarker β-amyloid and memory dysfunction is unclear.Method...
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Frontiers Media S.A.
2021-09-01
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Series: | Frontiers in Aging Neuroscience |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.721171/full |
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doaj-bf98e0075eef47338dfa61f02a6dce2d |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Binyin Li Miao Zhang Ikbeom Jang Ikbeom Jang Guanyu Ye Liche Zhou Guiying He Xiaozhu Lin Hongping Meng Xinyun Huang Wangxi Hai Shengdi Chen Biao Li Biao Li Jun Liu |
spellingShingle |
Binyin Li Miao Zhang Ikbeom Jang Ikbeom Jang Guanyu Ye Liche Zhou Guiying He Xiaozhu Lin Hongping Meng Xinyun Huang Wangxi Hai Shengdi Chen Biao Li Biao Li Jun Liu Amyloid-Beta Influences Memory via Functional Connectivity During Memory Retrieval in Alzheimer's Disease Frontiers in Aging Neuroscience amyloid magnetic resonance imaging Alzheimer disease memory neural connectivity |
author_facet |
Binyin Li Miao Zhang Ikbeom Jang Ikbeom Jang Guanyu Ye Liche Zhou Guiying He Xiaozhu Lin Hongping Meng Xinyun Huang Wangxi Hai Shengdi Chen Biao Li Biao Li Jun Liu |
author_sort |
Binyin Li |
title |
Amyloid-Beta Influences Memory via Functional Connectivity During Memory Retrieval in Alzheimer's Disease |
title_short |
Amyloid-Beta Influences Memory via Functional Connectivity During Memory Retrieval in Alzheimer's Disease |
title_full |
Amyloid-Beta Influences Memory via Functional Connectivity During Memory Retrieval in Alzheimer's Disease |
title_fullStr |
Amyloid-Beta Influences Memory via Functional Connectivity During Memory Retrieval in Alzheimer's Disease |
title_full_unstemmed |
Amyloid-Beta Influences Memory via Functional Connectivity During Memory Retrieval in Alzheimer's Disease |
title_sort |
amyloid-beta influences memory via functional connectivity during memory retrieval in alzheimer's disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2021-09-01 |
description |
Objective: Amnesia in Alzheimer's disease (AD) appears early and could be caused by encoding deficiency, consolidation dysfunction, and/or impairment in the retrieval of stored memory information. The relationship between AD pathology biomarker β-amyloid and memory dysfunction is unclear.Method: The memory task functional MRI and amyloid PET were simultaneously performed to investigate the relationship between memory performance, memory phase-related functional connectivity, and cortical β-amyloid deposition. We clustered functional networks during memory maintenance and compared network connectivity between groups in each memory phase. Mediation analysis was performed to investigate the mediator between β-amyloid and related cognitive performance.Results: Alzheimer's disease was primarily characterized by decreased functional connectivity in a data-driven network composed of an a priori default mode network, limbic network, and frontoparietal network during the memory maintenance (0.205 vs. 0.236, p = 0.04) and retrieval phase (0.159 vs. 0.183, p = 0.017). Within the network, AD had more regions with reduced connectivity during the retrieval than the maintenance and encoding phases (chi-square p = 0.01 and < 0.001). Furthermore, the global cortical β-amyloid negatively correlated with network connectivity during the memory retrieval phase (R = – 0.247, p = 0.032), with this relationship mediating the effect of cortical β-amyloid on memory performance (average causal mediation effect = – 0.05, p = 0.035).Conclusion: We demonstrated that AD had decreased connectivity in specific networks during the memory retrieval phase. Impaired functional connectivity during memory retrieval mediated the adverse effect of β-amyloid on memory. These findings help to elucidate the involvement of cortical β-amyloid (Aβ) in the memory performance in the early stages of AD. |
topic |
amyloid magnetic resonance imaging Alzheimer disease memory neural connectivity |
url |
https://www.frontiersin.org/articles/10.3389/fnagi.2021.721171/full |
work_keys_str_mv |
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doaj-bf98e0075eef47338dfa61f02a6dce2d2021-09-04T05:59:49ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-09-011310.3389/fnagi.2021.721171721171Amyloid-Beta Influences Memory via Functional Connectivity During Memory Retrieval in Alzheimer's DiseaseBinyin Li0Miao Zhang1Ikbeom Jang2Ikbeom Jang3Guanyu Ye4Liche Zhou5Guiying He6Xiaozhu Lin7Hongping Meng8Xinyun Huang9Wangxi Hai10Shengdi Chen11Biao Li12Biao Li13Jun Liu14Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United StatesDepartment of Radiology, Harvard Medical School, Boston, MA, United StatesDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCollaborative Innovation Center for Molecular Imaging of Precision Medicine, Ruijin Center, Shanghai, ChinaDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaObjective: Amnesia in Alzheimer's disease (AD) appears early and could be caused by encoding deficiency, consolidation dysfunction, and/or impairment in the retrieval of stored memory information. The relationship between AD pathology biomarker β-amyloid and memory dysfunction is unclear.Method: The memory task functional MRI and amyloid PET were simultaneously performed to investigate the relationship between memory performance, memory phase-related functional connectivity, and cortical β-amyloid deposition. We clustered functional networks during memory maintenance and compared network connectivity between groups in each memory phase. Mediation analysis was performed to investigate the mediator between β-amyloid and related cognitive performance.Results: Alzheimer's disease was primarily characterized by decreased functional connectivity in a data-driven network composed of an a priori default mode network, limbic network, and frontoparietal network during the memory maintenance (0.205 vs. 0.236, p = 0.04) and retrieval phase (0.159 vs. 0.183, p = 0.017). Within the network, AD had more regions with reduced connectivity during the retrieval than the maintenance and encoding phases (chi-square p = 0.01 and < 0.001). Furthermore, the global cortical β-amyloid negatively correlated with network connectivity during the memory retrieval phase (R = – 0.247, p = 0.032), with this relationship mediating the effect of cortical β-amyloid on memory performance (average causal mediation effect = – 0.05, p = 0.035).Conclusion: We demonstrated that AD had decreased connectivity in specific networks during the memory retrieval phase. Impaired functional connectivity during memory retrieval mediated the adverse effect of β-amyloid on memory. These findings help to elucidate the involvement of cortical β-amyloid (Aβ) in the memory performance in the early stages of AD.https://www.frontiersin.org/articles/10.3389/fnagi.2021.721171/fullamyloidmagnetic resonance imagingAlzheimer diseasememoryneural connectivity |