Role of Interferon-Gamma (Ifn-γ) in Immune Response Regulation in Hiv-1 and Hiv-1 + Mycobacterium Tuberculosis (Tb) Infected Patients / Interferona-gamma (Ifn-γ) Loma Imūnās Atbildes Regulēšanā Pacientiem Ar HIV-1 un HIV-1 + mycobacterium Tuberculosis
The aim of this research was to investigate the role of IFN-γ in interaction between IL-10, IL-18, IL-1b, CD4 cell counts and HIV-1 RNA viral load in the development of HIV-1 in patients co-infected with Mycobacterium tuberculosis (TB). The study was conducted by Rīga East Clinical University Hospit...
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doaj-bfa30283d2a24384a6cc2ec3c90fa9622021-09-05T13:59:54ZengSciendoProceedings of the Latvian Academy of Sciences. Section B, Natural Sciences1407-009X2016-08-0170421121410.1515/prolas-2016-0033prolas-2016-0033Role of Interferon-Gamma (Ifn-γ) in Immune Response Regulation in Hiv-1 and Hiv-1 + Mycobacterium Tuberculosis (Tb) Infected Patients / Interferona-gamma (Ifn-γ) Loma Imūnās Atbildes Regulēšanā Pacientiem Ar HIV-1 un HIV-1 + mycobacterium TuberculosisJanuškevica Inga0Rozentāle Baiba1Hagina Elvīra2Eglīte Jeīena3Kolupajeva Tatjana4Storozenko Jeīena5Guseva Ludmila6Lejnieks Aivars7Latvian Centre of Infectology, Rīga East Clinical University Hospital, Linezera iela 3, Rīga, LV-1006, LATVIALatvian Centre of Infectology, Rīga East Clinical University Hospital, Linezera iela 3, Rīga, LV-1006, LATVIARīga Stradiņš University, Joint Laboratory of Clinical Immunology and Immunogenetics, Rātsupītes iela 5, Rīga, LV-1067, LATVIARīga Stradiņš University, Joint Laboratory of Clinical Immunology and Immunogenetics, Rātsupītes iela 5, Rīga, LV-1067, LATVIALatvian Centre of Infectology, Rīga East Clinical University Hospital, Linezera iela 3, Rīga, LV-1006, LATVIALatvian Centre of Infectology, Rīga East Clinical University Hospital, Linezera iela 3, Rīga, LV-1006, LATVIALatvian Centre of Infectology, Rīga East Clinical University Hospital, Linezera iela 3, Rīga, LV-1006, LATVIADepartment of Internal Diseases, Rīga Stradiņš University, Rīga East Clinical University Hospital Latvia, Dzirciema iela 16, Rīga, LV-1007, LATVIAThe aim of this research was to investigate the role of IFN-γ in interaction between IL-10, IL-18, IL-1b, CD4 cell counts and HIV-1 RNA viral load in the development of HIV-1 in patients co-infected with Mycobacterium tuberculosis (TB). The study was conducted by Rīga East Clinical University Hospital with data from the HIV-1 register, in collaboration with the RSU Joint Laboratory of Clinical Immunology and Immunogenetics. 200 HIV-1 infected patients and 184 HIV-1 with TB co-infection patients divided in four groups were included in the study. IFN-γ, IL-10, IL-18, IL-1b levels were measured in serum with commercially enzyme-linked immunosorbent assay (ELISA Vector-Best Corporation, Novosibirsk, Russia). CD4 cell counts were measured by flow Partec IVD cytometry (USA). HIV-1 RNA quantification was performed using the COBAS AmpliPrep/COBAS Taqman HIV-1 Test (Germany). All groups were compared with each another. IFN-γ production was significantly lower, and IL-10 and CD4 cell counts were significantly higher, in HIV-1 patients without TB compared with the other groups. The group with HIV-1 and TB had significantly elevated IL-18 production. HIV patients with primary TB had significantly elevated IFN-γ production and HIV-1 RNA viral load and significantly lower IL-10 production.https://doi.org/10.1515/prolas-2016-0033ifn- γcytokinesmycobacterium tuberculosishiv-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Januškevica Inga Rozentāle Baiba Hagina Elvīra Eglīte Jeīena Kolupajeva Tatjana Storozenko Jeīena Guseva Ludmila Lejnieks Aivars |
spellingShingle |
Januškevica Inga Rozentāle Baiba Hagina Elvīra Eglīte Jeīena Kolupajeva Tatjana Storozenko Jeīena Guseva Ludmila Lejnieks Aivars Role of Interferon-Gamma (Ifn-γ) in Immune Response Regulation in Hiv-1 and Hiv-1 + Mycobacterium Tuberculosis (Tb) Infected Patients / Interferona-gamma (Ifn-γ) Loma Imūnās Atbildes Regulēšanā Pacientiem Ar HIV-1 un HIV-1 + mycobacterium Tuberculosis Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences ifn- γ cytokines mycobacterium tuberculosis hiv-1 |
author_facet |
Januškevica Inga Rozentāle Baiba Hagina Elvīra Eglīte Jeīena Kolupajeva Tatjana Storozenko Jeīena Guseva Ludmila Lejnieks Aivars |
author_sort |
Januškevica Inga |
title |
Role of Interferon-Gamma (Ifn-γ) in Immune Response Regulation in Hiv-1 and Hiv-1 + Mycobacterium Tuberculosis (Tb) Infected Patients / Interferona-gamma (Ifn-γ) Loma Imūnās Atbildes Regulēšanā Pacientiem Ar HIV-1 un HIV-1 + mycobacterium Tuberculosis |
title_short |
Role of Interferon-Gamma (Ifn-γ) in Immune Response Regulation in Hiv-1 and Hiv-1 + Mycobacterium Tuberculosis (Tb) Infected Patients / Interferona-gamma (Ifn-γ) Loma Imūnās Atbildes Regulēšanā Pacientiem Ar HIV-1 un HIV-1 + mycobacterium Tuberculosis |
title_full |
Role of Interferon-Gamma (Ifn-γ) in Immune Response Regulation in Hiv-1 and Hiv-1 + Mycobacterium Tuberculosis (Tb) Infected Patients / Interferona-gamma (Ifn-γ) Loma Imūnās Atbildes Regulēšanā Pacientiem Ar HIV-1 un HIV-1 + mycobacterium Tuberculosis |
title_fullStr |
Role of Interferon-Gamma (Ifn-γ) in Immune Response Regulation in Hiv-1 and Hiv-1 + Mycobacterium Tuberculosis (Tb) Infected Patients / Interferona-gamma (Ifn-γ) Loma Imūnās Atbildes Regulēšanā Pacientiem Ar HIV-1 un HIV-1 + mycobacterium Tuberculosis |
title_full_unstemmed |
Role of Interferon-Gamma (Ifn-γ) in Immune Response Regulation in Hiv-1 and Hiv-1 + Mycobacterium Tuberculosis (Tb) Infected Patients / Interferona-gamma (Ifn-γ) Loma Imūnās Atbildes Regulēšanā Pacientiem Ar HIV-1 un HIV-1 + mycobacterium Tuberculosis |
title_sort |
role of interferon-gamma (ifn-γ) in immune response regulation in hiv-1 and hiv-1 + mycobacterium tuberculosis (tb) infected patients / interferona-gamma (ifn-γ) loma imūnās atbildes regulēšanā pacientiem ar hiv-1 un hiv-1 + mycobacterium tuberculosis |
publisher |
Sciendo |
series |
Proceedings of the Latvian Academy of Sciences. Section B, Natural Sciences |
issn |
1407-009X |
publishDate |
2016-08-01 |
description |
The aim of this research was to investigate the role of IFN-γ in interaction between IL-10, IL-18, IL-1b, CD4 cell counts and HIV-1 RNA viral load in the development of HIV-1 in patients co-infected with Mycobacterium tuberculosis (TB). The study was conducted by Rīga East Clinical University Hospital with data from the HIV-1 register, in collaboration with the RSU Joint Laboratory of Clinical Immunology and Immunogenetics. 200 HIV-1 infected patients and 184 HIV-1 with TB co-infection patients divided in four groups were included in the study. IFN-γ, IL-10, IL-18, IL-1b levels were measured in serum with commercially enzyme-linked immunosorbent assay (ELISA Vector-Best Corporation, Novosibirsk, Russia). CD4 cell counts were measured by flow Partec IVD cytometry (USA). HIV-1 RNA quantification was performed using the COBAS AmpliPrep/COBAS Taqman HIV-1 Test (Germany). All groups were compared with each another. IFN-γ production was significantly lower, and IL-10 and CD4 cell counts were significantly higher, in HIV-1 patients without TB compared with the other groups. The group with HIV-1 and TB had significantly elevated IL-18 production. HIV patients with primary TB had significantly elevated IFN-γ production and HIV-1 RNA viral load and significantly lower IL-10 production. |
topic |
ifn- γ cytokines mycobacterium tuberculosis hiv-1 |
url |
https://doi.org/10.1515/prolas-2016-0033 |
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