Mitochondria, Oxidative Stress and Innate Immunity
Canonical functions of mitochondria include the regulation of cellular survival, orchestration of anabolic and metabolic pathways, as well as reactive oxygen species (ROS) signaling. Recent discoveries, nevertheless, have demonstrated that mitochondria are also critical elements to stimulate innate...
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doaj-bfb45f90b0e048138c8e1f3ea95570f42020-11-25T01:03:12ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-10-01910.3389/fphys.2018.01487409851Mitochondria, Oxidative Stress and Innate ImmunityYuxin Chen0Zhongyang Zhou1Wang Min2Wang Min3Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, ChinaCenter for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaCenter for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Pathology and the Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT, United StatesCanonical functions of mitochondria include the regulation of cellular survival, orchestration of anabolic and metabolic pathways, as well as reactive oxygen species (ROS) signaling. Recent discoveries, nevertheless, have demonstrated that mitochondria are also critical elements to stimulate innate immune signaling cascade that is able to intensify the inflammation upon cytotoxic stimuli beyond microbial infection. Here we review the expanding research field of mitochondria and oxidative stress in innate immune system to highlight the new mechanistic insights and discuss the pathological relevance of mitochondrial dysregulation induced aberrant innate immune responses in a growing list of sterile inflammatory diseases.https://www.frontiersin.org/article/10.3389/fphys.2018.01487/fullmitochondriainnate and adaptive immune responseinflammasomeROSthioredoxin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuxin Chen Zhongyang Zhou Wang Min Wang Min |
spellingShingle |
Yuxin Chen Zhongyang Zhou Wang Min Wang Min Mitochondria, Oxidative Stress and Innate Immunity Frontiers in Physiology mitochondria innate and adaptive immune response inflammasome ROS thioredoxin |
author_facet |
Yuxin Chen Zhongyang Zhou Wang Min Wang Min |
author_sort |
Yuxin Chen |
title |
Mitochondria, Oxidative Stress and Innate Immunity |
title_short |
Mitochondria, Oxidative Stress and Innate Immunity |
title_full |
Mitochondria, Oxidative Stress and Innate Immunity |
title_fullStr |
Mitochondria, Oxidative Stress and Innate Immunity |
title_full_unstemmed |
Mitochondria, Oxidative Stress and Innate Immunity |
title_sort |
mitochondria, oxidative stress and innate immunity |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2018-10-01 |
description |
Canonical functions of mitochondria include the regulation of cellular survival, orchestration of anabolic and metabolic pathways, as well as reactive oxygen species (ROS) signaling. Recent discoveries, nevertheless, have demonstrated that mitochondria are also critical elements to stimulate innate immune signaling cascade that is able to intensify the inflammation upon cytotoxic stimuli beyond microbial infection. Here we review the expanding research field of mitochondria and oxidative stress in innate immune system to highlight the new mechanistic insights and discuss the pathological relevance of mitochondrial dysregulation induced aberrant innate immune responses in a growing list of sterile inflammatory diseases. |
topic |
mitochondria innate and adaptive immune response inflammasome ROS thioredoxin |
url |
https://www.frontiersin.org/article/10.3389/fphys.2018.01487/full |
work_keys_str_mv |
AT yuxinchen mitochondriaoxidativestressandinnateimmunity AT zhongyangzhou mitochondriaoxidativestressandinnateimmunity AT wangmin mitochondriaoxidativestressandinnateimmunity AT wangmin mitochondriaoxidativestressandinnateimmunity |
_version_ |
1725201765970739200 |