Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant

TP53 mutations can cause increased risk for cancers. Here, the authors show a noncoding polymorphism in TP53 increases risk of some cancers but delays onset of others, and in a mouse model show this is via alteration of microRNA targeting sites that differ in impact depending on the tissue.

Bibliographic Details
Main Authors:	Qipan Deng, Hui Hu, Xinfang Yu, Shuanglin Liu, Lei Wang, Weiqun Chen, Chi Zhang, Zhaoyang Zeng, Ya Cao, Zijun Y. Xu-Monette, Ling Li, Mingzhi Zhang, Steven Rosenfeld, Shideng Bao, Eric Hsi, Ken H. Young, Zhongxin Lu, Yong Li
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-13002-x

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spelling	doaj-bfb5d0e480864011bab4f76558e15b112021-05-11T11:43:35ZengNature Publishing GroupNature Communications2041-17232019-11-0110111310.1038/s41467-019-13002-xTissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variantQipan Deng0Hui Hu1Xinfang Yu2Shuanglin Liu3Lei Wang4Weiqun Chen5Chi Zhang6Zhaoyang Zeng7Ya Cao8Zijun Y. Xu-Monette9Ling Li10Mingzhi Zhang11Steven Rosenfeld12Shideng Bao13Eric Hsi14Ken H. Young15Zhongxin Lu16Yong Li17Department of Medicine, Section of Epidemiology and Population Sciences, Baylor College of MedicineDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicDepartment of Medicine, Section of Epidemiology and Population Sciences, Baylor College of MedicineDepartment of Medicine, Section of Epidemiology and Population Sciences, Baylor College of MedicineDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicDepartment of Medical Laboratory, Central Hospital of WuhanDepartment of Medical Laboratory, Central Hospital of WuhanDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicKey Laboratory of Carcinogenesis and Invasion, Ministry of Education, Xiangya Hospital; Cancer Research Institute, Xiangya School of Medicine, Central South University; Key Laboratory of Carcinogenesis, Chinese Ministry of HealthDepartment of Pathology, Division of Hematopathology, Duke University Medical CenterDepartment of Oncology, the First Affiliated Hospital of Zhengzhou University; Lymphoma Diagnosis and Treatment Center of Henan ProvinceDepartment of Oncology, the First Affiliated Hospital of Zhengzhou University; Lymphoma Diagnosis and Treatment Center of Henan ProvinceDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicRobert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland ClinicDepartment of Pathology, Division of Hematopathology, Duke University Medical CenterDepartment of Medical Laboratory, Central Hospital of WuhanDepartment of Medicine, Section of Epidemiology and Population Sciences, Baylor College of MedicineTP53 mutations can cause increased risk for cancers. Here, the authors show a noncoding polymorphism in TP53 increases risk of some cancers but delays onset of others, and in a mouse model show this is via alteration of microRNA targeting sites that differ in impact depending on the tissue.https://doi.org/10.1038/s41467-019-13002-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Qipan Deng Hui Hu Xinfang Yu Shuanglin Liu Lei Wang Weiqun Chen Chi Zhang Zhaoyang Zeng Ya Cao Zijun Y. Xu-Monette Ling Li Mingzhi Zhang Steven Rosenfeld Shideng Bao Eric Hsi Ken H. Young Zhongxin Lu Yong Li
spellingShingle	Qipan Deng Hui Hu Xinfang Yu Shuanglin Liu Lei Wang Weiqun Chen Chi Zhang Zhaoyang Zeng Ya Cao Zijun Y. Xu-Monette Ling Li Mingzhi Zhang Steven Rosenfeld Shideng Bao Eric Hsi Ken H. Young Zhongxin Lu Yong Li Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant Nature Communications
author_facet	Qipan Deng Hui Hu Xinfang Yu Shuanglin Liu Lei Wang Weiqun Chen Chi Zhang Zhaoyang Zeng Ya Cao Zijun Y. Xu-Monette Ling Li Mingzhi Zhang Steven Rosenfeld Shideng Bao Eric Hsi Ken H. Young Zhongxin Lu Yong Li
author_sort	Qipan Deng
title	Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant
title_short	Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant
title_full	Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant
title_fullStr	Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant
title_full_unstemmed	Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant
title_sort	tissue-specific microrna expression alters cancer susceptibility conferred by a tp53 noncoding variant
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-11-01
description	TP53 mutations can cause increased risk for cancers. Here, the authors show a noncoding polymorphism in TP53 increases risk of some cancers but delays onset of others, and in a mouse model show this is via alteration of microRNA targeting sites that differ in impact depending on the tissue.
url	https://doi.org/10.1038/s41467-019-13002-x
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Tissue-specific microRNA expression alters cancer susceptibility conferred by a TP53 noncoding variant

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