Association between the MIF-173G/C Polymorphism and Serum MIF levels with Pulmonary Tuberculosis: A Meta-analysis
Abstract Many studies have indicated that Macrophage migration inhibitory factor (MIF)-173G/C gene polymorphisms are associated with susceptibility to pulmonary tuberculosis (PTB). Additionally, some studies have suggested that there are higher levels of serum MIF in patients with PTB than the contr...
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doaj-bfbe207b9df54b6888d06bdc6d76cf562020-12-08T00:02:59ZengNature Publishing GroupScientific Reports2045-23222017-03-01711810.1038/s41598-017-00299-1Association between the MIF-173G/C Polymorphism and Serum MIF levels with Pulmonary Tuberculosis: A Meta-analysisXiang Tong0Zhipeng Yan1Qilong Zhou2Sitong Liu3Jing Han4Yao Ma5Xue Yang6Hong Fan7Department of Respiratory Medicine and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan UniversityDepartment of Respiratory Medicine and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan UniversityInnovative Drug Research Centre, Chongqing UniversityDepartment of Respiratory Medicine and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan UniversityDepartment of Respiratory Medicine and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan UniversityDepartment of Respiratory Medicine and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan UniversityDepartment of Respiratory Medicine and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan UniversityDepartment of Respiratory Medicine and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan UniversityAbstract Many studies have indicated that Macrophage migration inhibitory factor (MIF)-173G/C gene polymorphisms are associated with susceptibility to pulmonary tuberculosis (PTB). Additionally, some studies have suggested that there are higher levels of serum MIF in patients with PTB than the controls. However, the results of these studies were underpowered. The current study aimed to precisely evaluate the association between the MIF-173G/C polymorphism and serum MIF concentrations with PTB. Therefore, a systematic literature search was preformed to identify studies involving the indicated association. Eleven articles (1316 cases and 1272 controls) were included in the study. The results indicated that the MIF-173G/C polymorphism was significantly associated with PTB susceptibility, especially in Asians. Interestingly, the results further detected that circulating MIF levels were significantly higher in patients with PTB than in healthy controls, but this was only the case among Asians. Moreover, the statistical significance was also similar to that of the high quality group. The present study indicated that the MIF-173G/C polymorphism may contribute to the development of PTB. Furthermore, significantly higher serum MIF levels were observed in PTB patients than in controls, which further indicated that the MIF may play an important role in PTB progression, particularly in Asians.https://doi.org/10.1038/s41598-017-00299-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiang Tong Zhipeng Yan Qilong Zhou Sitong Liu Jing Han Yao Ma Xue Yang Hong Fan |
spellingShingle |
Xiang Tong Zhipeng Yan Qilong Zhou Sitong Liu Jing Han Yao Ma Xue Yang Hong Fan Association between the MIF-173G/C Polymorphism and Serum MIF levels with Pulmonary Tuberculosis: A Meta-analysis Scientific Reports |
author_facet |
Xiang Tong Zhipeng Yan Qilong Zhou Sitong Liu Jing Han Yao Ma Xue Yang Hong Fan |
author_sort |
Xiang Tong |
title |
Association between the MIF-173G/C Polymorphism and Serum MIF levels with Pulmonary Tuberculosis: A Meta-analysis |
title_short |
Association between the MIF-173G/C Polymorphism and Serum MIF levels with Pulmonary Tuberculosis: A Meta-analysis |
title_full |
Association between the MIF-173G/C Polymorphism and Serum MIF levels with Pulmonary Tuberculosis: A Meta-analysis |
title_fullStr |
Association between the MIF-173G/C Polymorphism and Serum MIF levels with Pulmonary Tuberculosis: A Meta-analysis |
title_full_unstemmed |
Association between the MIF-173G/C Polymorphism and Serum MIF levels with Pulmonary Tuberculosis: A Meta-analysis |
title_sort |
association between the mif-173g/c polymorphism and serum mif levels with pulmonary tuberculosis: a meta-analysis |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-03-01 |
description |
Abstract Many studies have indicated that Macrophage migration inhibitory factor (MIF)-173G/C gene polymorphisms are associated with susceptibility to pulmonary tuberculosis (PTB). Additionally, some studies have suggested that there are higher levels of serum MIF in patients with PTB than the controls. However, the results of these studies were underpowered. The current study aimed to precisely evaluate the association between the MIF-173G/C polymorphism and serum MIF concentrations with PTB. Therefore, a systematic literature search was preformed to identify studies involving the indicated association. Eleven articles (1316 cases and 1272 controls) were included in the study. The results indicated that the MIF-173G/C polymorphism was significantly associated with PTB susceptibility, especially in Asians. Interestingly, the results further detected that circulating MIF levels were significantly higher in patients with PTB than in healthy controls, but this was only the case among Asians. Moreover, the statistical significance was also similar to that of the high quality group. The present study indicated that the MIF-173G/C polymorphism may contribute to the development of PTB. Furthermore, significantly higher serum MIF levels were observed in PTB patients than in controls, which further indicated that the MIF may play an important role in PTB progression, particularly in Asians. |
url |
https://doi.org/10.1038/s41598-017-00299-1 |
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