Sputum inflammatory cell-based classification of patients with acute exacerbation of chronic obstructive pulmonary disease.
<h4>Background</h4>Patients with chronic obstructive pulmonary disease (COPD) commonly suffer from acute exacerbations (AECOPD) and display varying disease severity. However, there is no available biomarker for the classification of AECOPD. This study is aimed at investigating the sputum...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
|
Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23741289/pdf/?tool=EBI |
id |
doaj-bfc757a8f40745be90c374b7d29999d3 |
---|---|
record_format |
Article |
spelling |
doaj-bfc757a8f40745be90c374b7d29999d32021-03-03T23:18:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0185e5767810.1371/journal.pone.0057678Sputum inflammatory cell-based classification of patients with acute exacerbation of chronic obstructive pulmonary disease.Peng GaoJie ZhangXiaoyan HeYuqiu HaoKe WangPeter G Gibson<h4>Background</h4>Patients with chronic obstructive pulmonary disease (COPD) commonly suffer from acute exacerbations (AECOPD) and display varying disease severity. However, there is no available biomarker for the classification of AECOPD. This study is aimed at investigating the sputum cellular profiles to classify patients with AECOPD.<h4>Methods</h4>A total of 83 patients with AECOPD and 26 healthy controls were recruited. Their demographic and clinical characteristics were recorded, and their lung function was examined. The phenotypes of sputum inflammatory cells were characterised, and the concentrations of sputum and serum amyloid-A (SAA), C-reactive protein (CRP), interleukin-6 (IL-6), and matrix metalloproteinase-9 (MMP-9) were measured. Based on the sputum inflammatory cell profiles, individual patients were categorized into one of the four subgroups with inflammatory eosinophilic, neutrophilic, paucigranulocytic, and mixed granulocytic AECOPD. Most AECOPD patients were reevaluated within 12-14 months after discharge.<h4>Results</h4>There were 10 (12%) eosinophilic, 36 (43%) neutrophilic, 5 (6%) mixed granulocytic, and 32 (39%) paucigranulocytic AECOPD patients. The patients with mixed granulocytic or neutrophilic AECOPD had a higher BODE score, more sputum inflammatory cells, lower lung function, and longer hospital stay, accompanied by higher concentrations of sputum MMP-9, IL-6 and CRP, and serum SAA, IL-6 and CRP. Notably, 83% of patients with neutrophilic AECOPD displayed evidence of bacterial infection and many of them responded poorly to standard therapies. In addition, patients with mixed granulocytic or neutrophilic stable COPD remained at lower lung functions and higher levels of inflammation.<h4>Conclusion</h4>Patients with AECOPD display heterogeneous inflammation, and the profiles of sputum inflammatory cells may be used as valuable biomarkers for the classification of AECOPD patients.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23741289/pdf/?tool=EBI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Peng Gao Jie Zhang Xiaoyan He Yuqiu Hao Ke Wang Peter G Gibson |
spellingShingle |
Peng Gao Jie Zhang Xiaoyan He Yuqiu Hao Ke Wang Peter G Gibson Sputum inflammatory cell-based classification of patients with acute exacerbation of chronic obstructive pulmonary disease. PLoS ONE |
author_facet |
Peng Gao Jie Zhang Xiaoyan He Yuqiu Hao Ke Wang Peter G Gibson |
author_sort |
Peng Gao |
title |
Sputum inflammatory cell-based classification of patients with acute exacerbation of chronic obstructive pulmonary disease. |
title_short |
Sputum inflammatory cell-based classification of patients with acute exacerbation of chronic obstructive pulmonary disease. |
title_full |
Sputum inflammatory cell-based classification of patients with acute exacerbation of chronic obstructive pulmonary disease. |
title_fullStr |
Sputum inflammatory cell-based classification of patients with acute exacerbation of chronic obstructive pulmonary disease. |
title_full_unstemmed |
Sputum inflammatory cell-based classification of patients with acute exacerbation of chronic obstructive pulmonary disease. |
title_sort |
sputum inflammatory cell-based classification of patients with acute exacerbation of chronic obstructive pulmonary disease. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
<h4>Background</h4>Patients with chronic obstructive pulmonary disease (COPD) commonly suffer from acute exacerbations (AECOPD) and display varying disease severity. However, there is no available biomarker for the classification of AECOPD. This study is aimed at investigating the sputum cellular profiles to classify patients with AECOPD.<h4>Methods</h4>A total of 83 patients with AECOPD and 26 healthy controls were recruited. Their demographic and clinical characteristics were recorded, and their lung function was examined. The phenotypes of sputum inflammatory cells were characterised, and the concentrations of sputum and serum amyloid-A (SAA), C-reactive protein (CRP), interleukin-6 (IL-6), and matrix metalloproteinase-9 (MMP-9) were measured. Based on the sputum inflammatory cell profiles, individual patients were categorized into one of the four subgroups with inflammatory eosinophilic, neutrophilic, paucigranulocytic, and mixed granulocytic AECOPD. Most AECOPD patients were reevaluated within 12-14 months after discharge.<h4>Results</h4>There were 10 (12%) eosinophilic, 36 (43%) neutrophilic, 5 (6%) mixed granulocytic, and 32 (39%) paucigranulocytic AECOPD patients. The patients with mixed granulocytic or neutrophilic AECOPD had a higher BODE score, more sputum inflammatory cells, lower lung function, and longer hospital stay, accompanied by higher concentrations of sputum MMP-9, IL-6 and CRP, and serum SAA, IL-6 and CRP. Notably, 83% of patients with neutrophilic AECOPD displayed evidence of bacterial infection and many of them responded poorly to standard therapies. In addition, patients with mixed granulocytic or neutrophilic stable COPD remained at lower lung functions and higher levels of inflammation.<h4>Conclusion</h4>Patients with AECOPD display heterogeneous inflammation, and the profiles of sputum inflammatory cells may be used as valuable biomarkers for the classification of AECOPD patients. |
url |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23741289/pdf/?tool=EBI |
work_keys_str_mv |
AT penggao sputuminflammatorycellbasedclassificationofpatientswithacuteexacerbationofchronicobstructivepulmonarydisease AT jiezhang sputuminflammatorycellbasedclassificationofpatientswithacuteexacerbationofchronicobstructivepulmonarydisease AT xiaoyanhe sputuminflammatorycellbasedclassificationofpatientswithacuteexacerbationofchronicobstructivepulmonarydisease AT yuqiuhao sputuminflammatorycellbasedclassificationofpatientswithacuteexacerbationofchronicobstructivepulmonarydisease AT kewang sputuminflammatorycellbasedclassificationofpatientswithacuteexacerbationofchronicobstructivepulmonarydisease AT peterggibson sputuminflammatorycellbasedclassificationofpatientswithacuteexacerbationofchronicobstructivepulmonarydisease |
_version_ |
1714811691384963072 |