Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate
The energy required to fuse synaptic vesicles with the plasma membrane (‘activation energy’) is considered a major determinant in synaptic efficacy. From reaction rate theory, we predict that a class of modulations exists, which utilize linear modulation of the energy barrier for fusion to achieve s...
Main Authors: | Sebastiaan Schotten, Marieke Meijer, Alexander Matthias Walter, Vincent Huson, Lauren Mamer, Lawrence Kalogreades, Mirelle ter Veer, Marvin Ruiter, Nils Brose, Christian Rosenmund, Jakob Balslev Sørensen, Matthijs Verhage, Lennart Niels Cornelisse |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2015-04-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/05531 |
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