EFFECTS OF LOW-INTENSITY MICROWAVE IRRADIATION UPON INTRACELLULAR SIGNALING OF MONONUCLEAR CELLS IN PNEUMONIA PATIENTS

• Main Authors: I. V. Terekhov, K. A. Solodukhin, V. S. Nikiforov, M. S. Gromov, V. K. Parfenyk, S. S. Bondar
• Format: Article
• Language: Russian
• Published: SPb RAACI 2014-07-01
• Series: Medicinskaâ Immunologiâ
• Subjects: microwave radiation; mononuclear cells; cytokines; transcription factors; pneumonia
• Online Access: https://www.mimmun.ru/mimmun/article/view/614
• ISSN: 1563-0625; 2313-741X

Abstract. Some molecular biomarkers of peripheral blood mononuclear cells (PBMC) were studied in patients 18 to 30 years old with community-acquired pneumonia (n = 30) and healthy persons (n = 15), along with testing appropriate biological effects of low-intensity microwave irradiation (1000 MHz), at a dose rate of 100 pW/cm2. Concentrations of cytokines and some molecules providing intracellular signal transduction in PBMC were measured by ELISA tests. Biological action of microwave radiation was studied after 1-hour irradiation of whole blood, followed by incubation for 24 hours. A single round of irradiation was shown to cause an increase in NFκB content by 12.5% (р = 0.001); IκB by 21.1% (р = 0.0007); phosphorylated JNK1/2, by 18.2% (р = 0.052); p21 protein amounts, by 56.2% (р = 0.031); IL-2, by 8.5% (р = 0.08); IL-4, by 17.6% (р = 0.031). Antioxidant potential of PBMC supernatewas augmented by 65.2% (р < 0,001). Hence, a single 1000-MHz microwave irradiation modulates activity of intracellular events in PBMCs from pneumonia patients.