Self-association of MreC as a regulatory signal in bacterial cell wall elongation

Self-association of MreC as a regulatory signal in bacterial cell wall elongation

MreC is a membrane-associated protein that modulates the activity of the elongasome, a protein complex that controls cell wall formation in rod-shaped bacteria. Here, the authors use electron cryo-microscopy and X-ray crystallography to determine the structure of a self-associated form of MreC in at...

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Main Authors: Alexandre Martins, Carlos Contreras-Martel, Manon Janet-Maitre, Mayara M. Miyachiro, Leandro F. Estrozi, Daniel Maragno Trindade, Caíque C. Malospirito, Fernanda Rodrigues-Costa, Lionel Imbert, Viviana Job, Guy Schoehn, Ina Attrée, Andréa Dessen
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22957-9
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spelling doaj-bfd9056a555a4b14acc5e2a6e24d19b12021-05-23T11:13:55ZengNature Publishing GroupNature Communications2041-17232021-05-0112111010.1038/s41467-021-22957-9Self-association of MreC as a regulatory signal in bacterial cell wall elongationAlexandre Martins0Carlos Contreras-Martel1Manon Janet-Maitre2Mayara M. Miyachiro3Leandro F. Estrozi4Daniel Maragno Trindade5Caíque C. Malospirito6Fernanda Rodrigues-Costa7Lionel Imbert8Viviana Job9Guy Schoehn10Ina Attrée11Andréa Dessen12Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS)Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS)Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS)Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS)Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS)Brazilian Biosciences National Laboratory (LNBio), CNPEMBrazilian Biosciences National Laboratory (LNBio), CNPEMBrazilian Biosciences National Laboratory (LNBio), CNPEMUniv. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS)Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS)Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS)Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS)Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS)MreC is a membrane-associated protein that modulates the activity of the elongasome, a protein complex that controls cell wall formation in rod-shaped bacteria. Here, the authors use electron cryo-microscopy and X-ray crystallography to determine the structure of a self-associated form of MreC in atomic detail.https://doi.org/10.1038/s41467-021-22957-9
collection DOAJ
language English
format Article
sources DOAJ
author Alexandre Martins
Carlos Contreras-Martel
Manon Janet-Maitre
Mayara M. Miyachiro
Leandro F. Estrozi
Daniel Maragno Trindade
Caíque C. Malospirito
Fernanda Rodrigues-Costa
Lionel Imbert
Viviana Job
Guy Schoehn
Ina Attrée
Andréa Dessen
spellingShingle Alexandre Martins
Carlos Contreras-Martel
Manon Janet-Maitre
Mayara M. Miyachiro
Leandro F. Estrozi
Daniel Maragno Trindade
Caíque C. Malospirito
Fernanda Rodrigues-Costa
Lionel Imbert
Viviana Job
Guy Schoehn
Ina Attrée
Andréa Dessen
Self-association of MreC as a regulatory signal in bacterial cell wall elongation
Nature Communications
author_facet Alexandre Martins
Carlos Contreras-Martel
Manon Janet-Maitre
Mayara M. Miyachiro
Leandro F. Estrozi
Daniel Maragno Trindade
Caíque C. Malospirito
Fernanda Rodrigues-Costa
Lionel Imbert
Viviana Job
Guy Schoehn
Ina Attrée
Andréa Dessen
author_sort Alexandre Martins
title Self-association of MreC as a regulatory signal in bacterial cell wall elongation
title_short Self-association of MreC as a regulatory signal in bacterial cell wall elongation
title_full Self-association of MreC as a regulatory signal in bacterial cell wall elongation
title_fullStr Self-association of MreC as a regulatory signal in bacterial cell wall elongation
title_full_unstemmed Self-association of MreC as a regulatory signal in bacterial cell wall elongation
title_sort self-association of mrec as a regulatory signal in bacterial cell wall elongation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-05-01
description MreC is a membrane-associated protein that modulates the activity of the elongasome, a protein complex that controls cell wall formation in rod-shaped bacteria. Here, the authors use electron cryo-microscopy and X-ray crystallography to determine the structure of a self-associated form of MreC in atomic detail.
url https://doi.org/10.1038/s41467-021-22957-9
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