Chromosome Arm-Specific Long Telomeres: A New Clonal Event in Primary Chronic Myelogenous Leukemia Cells
Previous studies demonstrated that critically shortened telomere lengths correlate with the chromosome instability in carcinogenesis. However, little has been noticed regarding the correlation of long telomeres at specific chromosomes with malignant disorders. We studied relative telomere lengths (...
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doaj-bffe01a3fae44e73b6fd0aab33a26a0b2020-11-24T23:46:03ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55861522-80022011-06-0113655056010.1593/neo.11358Chromosome Arm-Specific Long Telomeres: A New Clonal Event in Primary Chronic Myelogenous Leukemia CellsOumar Samassekou0Huiyu Li1Josée Hébert2Aimé Ntwari3Haixia Wang4Catherine Grenier Cliché5Eric Bouchard6Shiang Huang7Ju Yan8Division of Genetics, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, CanadaCenter for Stem Cell Research and Application, Institute of Hematology in Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, PR ChinaLeukemia Cell Bank of Quebec and Division of Hematology, Maisonneuve-Rosemont Hospital, Montreal, Quebec, CanadaDivision of Genetics, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, CanadaCenter for Stem Cell Research and Application, Institute of Hematology in Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, PR ChinaDivision of Genetics, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, CanadaDivision of Genetics, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, CanadaCenter for Stem Cell Research and Application, Institute of Hematology in Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, PR ChinaDivision of Genetics, Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada Previous studies demonstrated that critically shortened telomere lengths correlate with the chromosome instability in carcinogenesis. However, little has been noticed regarding the correlation of long telomeres at specific chromosomes with malignant disorders. We studied relative telomere lengths (RTLs) for individual chromosomes using the quantitative fluorescence in situ hybridization technique in a cohort of 32 patients with chronic myeloid leukemia (CML) and 32 normal samples. We found that telomeres at some specific chromosome arms remain well maintained or even lengthened in a high frequency (27/32) of leukemia cases. In particular, 10 chromosome arms, 4q, 5p, 7q, 11p, 13p, 13q, 14p, 15p, 18p, and Xp, with long telomeres were consistently identified in different samples, and six of them (4q, 5p, 13p, 13q, 14p, and Xp) with relatively long telomeres were also observed in normal samples, but they appeared in lower occurrence rate and shorter RTL than in CML samples. Our results strongly indicate the presence of a special leukemia cell population, or a clone, originated from a common progenitor that is characterized with chromosome arm-specific long telomeres. We suggest that relatively long telomeres located at key chromosomes could be preferentially maintained or further elongated during the early stage of malignant transformation. http://www.sciencedirect.com/science/article/pii/S1476558611800461 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Oumar Samassekou Huiyu Li Josée Hébert Aimé Ntwari Haixia Wang Catherine Grenier Cliché Eric Bouchard Shiang Huang Ju Yan |
spellingShingle |
Oumar Samassekou Huiyu Li Josée Hébert Aimé Ntwari Haixia Wang Catherine Grenier Cliché Eric Bouchard Shiang Huang Ju Yan Chromosome Arm-Specific Long Telomeres: A New Clonal Event in Primary Chronic Myelogenous Leukemia Cells Neoplasia: An International Journal for Oncology Research |
author_facet |
Oumar Samassekou Huiyu Li Josée Hébert Aimé Ntwari Haixia Wang Catherine Grenier Cliché Eric Bouchard Shiang Huang Ju Yan |
author_sort |
Oumar Samassekou |
title |
Chromosome Arm-Specific Long Telomeres: A New Clonal Event in Primary Chronic Myelogenous Leukemia Cells |
title_short |
Chromosome Arm-Specific Long Telomeres: A New Clonal Event in Primary Chronic Myelogenous Leukemia Cells |
title_full |
Chromosome Arm-Specific Long Telomeres: A New Clonal Event in Primary Chronic Myelogenous Leukemia Cells |
title_fullStr |
Chromosome Arm-Specific Long Telomeres: A New Clonal Event in Primary Chronic Myelogenous Leukemia Cells |
title_full_unstemmed |
Chromosome Arm-Specific Long Telomeres: A New Clonal Event in Primary Chronic Myelogenous Leukemia Cells |
title_sort |
chromosome arm-specific long telomeres: a new clonal event in primary chronic myelogenous leukemia cells |
publisher |
Elsevier |
series |
Neoplasia: An International Journal for Oncology Research |
issn |
1476-5586 1522-8002 |
publishDate |
2011-06-01 |
description |
Previous studies demonstrated that critically shortened telomere lengths correlate with the chromosome instability in carcinogenesis. However, little has been noticed regarding the correlation of long telomeres at specific chromosomes with malignant disorders. We studied relative telomere lengths (RTLs) for individual chromosomes using the quantitative fluorescence in situ hybridization technique in a cohort of 32 patients with chronic myeloid leukemia (CML) and 32 normal samples. We found that telomeres at some specific chromosome arms remain well maintained or even lengthened in a high frequency (27/32) of leukemia cases. In particular, 10 chromosome arms, 4q, 5p, 7q, 11p, 13p, 13q, 14p, 15p, 18p, and Xp, with long telomeres were consistently identified in different samples, and six of them (4q, 5p, 13p, 13q, 14p, and Xp) with relatively long telomeres were also observed in normal samples, but they appeared in lower occurrence rate and shorter RTL than in CML samples. Our results strongly indicate the presence of a special leukemia cell population, or a clone, originated from a common progenitor that is characterized with chromosome arm-specific long telomeres. We suggest that relatively long telomeres located at key chromosomes could be preferentially maintained or further elongated during the early stage of malignant transformation.
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url |
http://www.sciencedirect.com/science/article/pii/S1476558611800461 |
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