Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling

Time of day influences immune responses and lethality in response to LPS, with survival greatest at the beginning compared to the end of the light cycle. Here the authors show that feeding, rather than light, controls time-of-day dependent LPS sensitivity through the liver clock and hepatic FXR sign...

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Main Authors:	Sarah S. Geiger, Javier Traba, Nathan Richoz, Taylor K. Farley, Stephen R. Brooks, Franziska Petermann, Lingdi Wang, Frank J. Gonzalez, Michael N. Sack, Richard M. Siegel
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-22961-z

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spelling	doaj-c006a892d73b44e6afaa5d1292253d772021-05-16T11:10:49ZengNature Publishing GroupNature Communications2041-17232021-05-0112111210.1038/s41467-021-22961-zFeeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signallingSarah S. Geiger0Javier Traba1Nathan Richoz2Taylor K. Farley3Stephen R. Brooks4Franziska Petermann5Lingdi Wang6Frank J. Gonzalez7Michael N. Sack8Richard M. Siegel9Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of HealthLaboratory of Mitochondrial Biology and Metabolism, National Heart Lung and Blood Institute (NHLBI), National Institutes of HealthImmunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of HealthImmunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of HealthBiodata Mining and Discovery Section, Office of Science and Technology, NIAMS, NIHLymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of HealthLaboratory of Mitochondrial Biology and Metabolism, National Heart Lung and Blood Institute (NHLBI), National Institutes of HealthLaboratory of Metabolism, National Cancer Institute (NCI), National Institutes of HealthLaboratory of Mitochondrial Biology and Metabolism, National Heart Lung and Blood Institute (NHLBI), National Institutes of HealthImmunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of HealthTime of day influences immune responses and lethality in response to LPS, with survival greatest at the beginning compared to the end of the light cycle. Here the authors show that feeding, rather than light, controls time-of-day dependent LPS sensitivity through the liver clock and hepatic FXR signalling.https://doi.org/10.1038/s41467-021-22961-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sarah S. Geiger Javier Traba Nathan Richoz Taylor K. Farley Stephen R. Brooks Franziska Petermann Lingdi Wang Frank J. Gonzalez Michael N. Sack Richard M. Siegel
spellingShingle	Sarah S. Geiger Javier Traba Nathan Richoz Taylor K. Farley Stephen R. Brooks Franziska Petermann Lingdi Wang Frank J. Gonzalez Michael N. Sack Richard M. Siegel Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling Nature Communications
author_facet	Sarah S. Geiger Javier Traba Nathan Richoz Taylor K. Farley Stephen R. Brooks Franziska Petermann Lingdi Wang Frank J. Gonzalez Michael N. Sack Richard M. Siegel
author_sort	Sarah S. Geiger
title	Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling
title_short	Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling
title_full	Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling
title_fullStr	Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling
title_full_unstemmed	Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling
title_sort	feeding-induced resistance to acute lethal sepsis is dependent on hepatic bmal1 and fxr signalling
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-05-01
description	Time of day influences immune responses and lethality in response to LPS, with survival greatest at the beginning compared to the end of the light cycle. Here the authors show that feeding, rather than light, controls time-of-day dependent LPS sensitivity through the liver clock and hepatic FXR signalling.
url	https://doi.org/10.1038/s41467-021-22961-z
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Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling

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