Effect of selenium on the course of a postoperative period after liver transplantation
Objective: to study the effect of selenium on the course of a postoperative period in patients after orthotopic liver transplantation (OLT).Subjects and methods. The prospective controlled randomized study enrolled 30 patients after OLT. Selenium (Selenase, Biosyn) was administered in Group 1 (n = 1...
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2018-08-01
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doaj-c00e89a64dbe4c0bb39ec842a1e6208e2021-07-28T20:55:24ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentTransplantologiâ2074-05062542-09092018-08-0102151810.23873/2074-0506-2009-0-2-15-18247Effect of selenium on the course of a postoperative period after liver transplantationM. Sh. Khubutia0S. V. Zhuravel1A. M. Talyzin2V. V. Kiselev3Ye. R. Dorofeyeva4N. K. Kuznetsova5A. V. Chzhao6N.V. Sklifosovsky Research Institute of Emergency CareN.V. Sklifosovsky Research Institute of Emergency CareN.V. Sklifosovsky Research Institute of Emergency CareN.V. Sklifosovsky Research Institute of Emergency CareN.V. Sklifosovsky Research Institute of Emergency CareN.V. Sklifosovsky Research Institute of Emergency CareN.V. Sklifosovsky Research Institute of Emergency CareObjective: to study the effect of selenium on the course of a postoperative period in patients after orthotopic liver transplantation (OLT).Subjects and methods. The prospective controlled randomized study enrolled 30 patients after OLT. Selenium (Selenase, Biosyn) was administered in Group 1 (n = 15) within 5 days operatively. The agent was not used in complex therapy in Group 2 (n = 15).Results. After OLT, the plasma levels of selenium were much more than the normal value. In Group 1, the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were significantly lower on day 3 after OLT and those of urea and creatinine significantly decreased by day 7. A significant difference was found in scores on day 7, as shown by the analysis of the patients' condition by the SOFA scale. The patients who needed venovenous hemodiafiltration (VVHDF) were more than in those who did not use selenium.Conclusion. Selenium levels considerably decrease after liver transplantation. Selenase has a hepatoprotective effect, alleviates the manifestations of a systemic inflammatory response, and reduces the frequency of VVHDF use.https://www.jtransplantologiya.ru/jour/article/view/258orthotopic liver transplantationselenium levelselenase |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M. Sh. Khubutia S. V. Zhuravel A. M. Talyzin V. V. Kiselev Ye. R. Dorofeyeva N. K. Kuznetsova A. V. Chzhao |
spellingShingle |
M. Sh. Khubutia S. V. Zhuravel A. M. Talyzin V. V. Kiselev Ye. R. Dorofeyeva N. K. Kuznetsova A. V. Chzhao Effect of selenium on the course of a postoperative period after liver transplantation Transplantologiâ orthotopic liver transplantation selenium level selenase |
author_facet |
M. Sh. Khubutia S. V. Zhuravel A. M. Talyzin V. V. Kiselev Ye. R. Dorofeyeva N. K. Kuznetsova A. V. Chzhao |
author_sort |
M. Sh. Khubutia |
title |
Effect of selenium on the course of a postoperative period after liver transplantation |
title_short |
Effect of selenium on the course of a postoperative period after liver transplantation |
title_full |
Effect of selenium on the course of a postoperative period after liver transplantation |
title_fullStr |
Effect of selenium on the course of a postoperative period after liver transplantation |
title_full_unstemmed |
Effect of selenium on the course of a postoperative period after liver transplantation |
title_sort |
effect of selenium on the course of a postoperative period after liver transplantation |
publisher |
N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
series |
Transplantologiâ |
issn |
2074-0506 2542-0909 |
publishDate |
2018-08-01 |
description |
Objective: to study the effect of selenium on the course of a postoperative period in patients after orthotopic liver transplantation (OLT).Subjects and methods. The prospective controlled randomized study enrolled 30 patients after OLT. Selenium (Selenase, Biosyn) was administered in Group 1 (n = 15) within 5 days operatively. The agent was not used in complex therapy in Group 2 (n = 15).Results. After OLT, the plasma levels of selenium were much more than the normal value. In Group 1, the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were significantly lower on day 3 after OLT and those of urea and creatinine significantly decreased by day 7. A significant difference was found in scores on day 7, as shown by the analysis of the patients' condition by the SOFA scale. The patients who needed venovenous hemodiafiltration (VVHDF) were more than in those who did not use selenium.Conclusion. Selenium levels considerably decrease after liver transplantation. Selenase has a hepatoprotective effect, alleviates the manifestations of a systemic inflammatory response, and reduces the frequency of VVHDF use. |
topic |
orthotopic liver transplantation selenium level selenase |
url |
https://www.jtransplantologiya.ru/jour/article/view/258 |
work_keys_str_mv |
AT mshkhubutia effectofseleniumonthecourseofapostoperativeperiodafterlivertransplantation AT svzhuravel effectofseleniumonthecourseofapostoperativeperiodafterlivertransplantation AT amtalyzin effectofseleniumonthecourseofapostoperativeperiodafterlivertransplantation AT vvkiselev effectofseleniumonthecourseofapostoperativeperiodafterlivertransplantation AT yerdorofeyeva effectofseleniumonthecourseofapostoperativeperiodafterlivertransplantation AT nkkuznetsova effectofseleniumonthecourseofapostoperativeperiodafterlivertransplantation AT avchzhao effectofseleniumonthecourseofapostoperativeperiodafterlivertransplantation |
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1721264646539706368 |