Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway

Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway

Tight regulation of signaling from receptor tyrosine kinases is required for normal cellular functions and uncontrolled signaling can lead to cancer. Fibroblast growth factor receptor 2 (FGFR2) is a receptor tyrosine kinase that induces proliferation and migration. Deregulation of FGFR2 contributes...

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Bibliographic Details
Main Authors: Patrycja Szybowska, Michal Kostas, Jørgen Wesche, Antoni Wiedlocha, Ellen Margrethe Haugsten
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cells
Subjects:
FGFR2
ERK1/2
phosphorylation
serine
negative feedback loop
cancer
Online Access:https://www.mdpi.com/2073-4409/8/6/518

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