Compound K, a Metabolite of Ginseng Saponin, Induces Mitochondria-Dependent and Caspase-Dependent Apoptosis via the Generation of Reactive Oxygen Species in Human Colon Cancer Cells

Compound K, a Metabolite of Ginseng Saponin, Induces Mitochondria-Dependent and Caspase-Dependent Apoptosis via the Generation of Reactive Oxygen Species in Human Colon Cancer Cells

The objective of this study was to elucidate the cytotoxic mechanism of Compound K, with respect to the involvement of reactive oxygen species (ROS) and the mitochondrial involved apoptosis, in HT-29 human colon cancer cells. Compound K exhibited a concentration of 50% growth inhibition (IC50) at 20...

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Bibliographic Details
Main Authors: Jin Won Hyun, Weon Young Chang, Jae Hyuck Choi, Bum Joon Kim, Hee Sun Kim, Dong Hyun Kim, Ki Cheon Kim, Chae Moon Lim, Kyoung Ah Kang, In Kyung Lee
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:International Journal of Molecular Sciences
Subjects:
Compound K
reactive oxygen species
mitochondrial membrane potential
c-Jun NH2-terminal kinase
p38 mitogen-activated protein kinase
Online Access:http://www.mdpi.com/1422-0067/11/12/4916/

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