Rhabdo-immunodeficiency virus, a murine model of acute HIV-1 infection

Rhabdo-immunodeficiency virus, a murine model of acute HIV-1 infection

Numerous challenges have impeded HIV-1 vaccine development. Among these is the lack of a convenient small animal model in which to study antibody elicitation and efficacy. We describe a chimeric Rhabdo-Immunodeficiency virus (RhIV) murine model that recapitulates key features of HIV-1 entry, tropism...

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Bibliographic Details
Main Authors:	Rachel A Liberatore, Emily J Mastrocola, Elena Cassella, Fabian Schmidt, Jessie R Willen, Dennis Voronin, Trinity M Zang, Theodora Hatziioannou, Paul D Bieniasz
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2019-10-01
Series:	eLife
Subjects:	HIV-1 antibody envelope CD4 CCR5 neutralization
Online Access:	https://elifesciences.org/articles/49875

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