In vitro cytotoxicity of allelopathic plants Adonis vernalis L. Origanum vulgare ssp. vulgare L. and Nepeta nuda subsp. nuda

• Main Authors: Koleva Vanya, Dragoeva Asya, Stoyanova Zheni, Yordanova Zhenia, Ali Selime, Uzunov Nikolay M., Melendez-Alafort Laura, Rosato Antonio, Enchev Dobromir D.
• Format: Article
• Language: English
• Published: Sciendo 2018-03-01
• Series: Acta Scientifica Naturalis
• Subjects: water extracts; human hepatomacell line sk-hep-1; adonis vernalis l. (ranunculaceae); origanum vulgare ssp. vulgare l. and nepeta nuda subsp. nuda (lamiaceae)
• Online Access: https://doi.org/10.2478/asn-2018-0009
• ISSN: 2367-5144

Medicinal plants produce various secondary metabolites as a part of their chemical defence and survival in nature. These compounds have a wide range of biological activities. Nowadays, medicinal plants are used as source of allelochemicals and new effective anticancer agents. Our previous studies revealed allelopathic potential of water extracts of Adonis vernalis L. (Ranunculaceae), Origanum vulgare ssp. vulgare L. and Nepeta nuda subsp. nuda (Lamiaceae). Present study aimed to evaluate the effect of the same extracts in vitro on human hepatoma cell line SK-HEP-1. Cell proliferation/viability was assessed using Premixed WST-1 Cell Proliferation Reagent.