Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in Fish
Iron is a trace element, essential to support life due to its inherent ability to exchange electrons with a variety of molecules. The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic microorganisms and their hosts. During evolution, the shared requirement of micr...
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doaj-c03ae992c7e64f4c92da0964a20e3f0e2020-11-24T21:56:13ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-06-01910.3389/fimmu.2018.01296376176Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in FishEstefanía Tarifeño-Saldivia0Estefanía Tarifeño-Saldivia1Andrea Aguilar2David Contreras3Luis Mercado4Byron Morales-Lange5Katherine Márquez6Adolfo Henríquez7Camila Riquelme-Vidal8Sebastian Boltana9Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Concepcion, Concepción, ChileInterdisciplinary Center for Aquaculture Research (INCAR), Department of Oceanography, Biotechnology Center, University of Concepción, Concepción, ChileInterdisciplinary Center for Aquaculture Research (INCAR), Department of Oceanography, Biotechnology Center, University of Concepción, Concepción, ChileRenewable Resources Laboratory, Biotechnology Center, University of Concepción, University Campus, Concepción, ChileGrupo de Marcadores Inmunológicos, Instituto de Biología, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso, ChileGrupo de Marcadores Inmunológicos, Instituto de Biología, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso, ChileRenewable Resources Laboratory, Biotechnology Center, University of Concepción, University Campus, Concepción, ChileRenewable Resources Laboratory, Biotechnology Center, University of Concepción, University Campus, Concepción, ChileInterdisciplinary Center for Aquaculture Research (INCAR), Department of Oceanography, Biotechnology Center, University of Concepción, Concepción, ChileInterdisciplinary Center for Aquaculture Research (INCAR), Department of Oceanography, Biotechnology Center, University of Concepción, Concepción, ChileIron is a trace element, essential to support life due to its inherent ability to exchange electrons with a variety of molecules. The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic microorganisms and their hosts. During evolution, the shared requirement of micro- and macro-organisms for this important nutrient has shaped the pathogen–host relationship. Infectious pancreatic necrosis virus (IPNv) affects salmonids constituting a sanitary problem for this industry as it has an important impact on post-smolt survival. While immune modulation induced by IPNv infection has been widely characterized on Salmo salar, viral impact on iron host metabolism has not yet been elucidated. In the present work, we evaluate short-term effect of IPNv on several infected tissues from Salmo salar. We observed that IPNv displayed high tropism to headkidney, which directly correlates with a rise in oxidative stress and antiviral responses. Transcriptional profiling on headkidney showed a massive modulation of gene expression, from which biological pathways involved with iron metabolism were remarkable. Our findings suggest that IPNv infection increase oxidative stress on headkidney as a consequence of iron overload induced by a massive upregulation of genes involved in iron metabolism.https://www.frontiersin.org/article/10.3389/fimmu.2018.01296/fulliron overloadelectronic paramagnetic resonance spectroscopynutritional immunityoxidative stressinfectious pancreaticc necrosis virusRNA-seq |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Estefanía Tarifeño-Saldivia Estefanía Tarifeño-Saldivia Andrea Aguilar David Contreras Luis Mercado Byron Morales-Lange Katherine Márquez Adolfo Henríquez Camila Riquelme-Vidal Sebastian Boltana |
spellingShingle |
Estefanía Tarifeño-Saldivia Estefanía Tarifeño-Saldivia Andrea Aguilar David Contreras Luis Mercado Byron Morales-Lange Katherine Márquez Adolfo Henríquez Camila Riquelme-Vidal Sebastian Boltana Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in Fish Frontiers in Immunology iron overload electronic paramagnetic resonance spectroscopy nutritional immunity oxidative stress infectious pancreaticc necrosis virus RNA-seq |
author_facet |
Estefanía Tarifeño-Saldivia Estefanía Tarifeño-Saldivia Andrea Aguilar David Contreras Luis Mercado Byron Morales-Lange Katherine Márquez Adolfo Henríquez Camila Riquelme-Vidal Sebastian Boltana |
author_sort |
Estefanía Tarifeño-Saldivia |
title |
Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in Fish |
title_short |
Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in Fish |
title_full |
Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in Fish |
title_fullStr |
Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in Fish |
title_full_unstemmed |
Iron Overload Is Associated With Oxidative Stress and Nutritional Immunity During Viral Infection in Fish |
title_sort |
iron overload is associated with oxidative stress and nutritional immunity during viral infection in fish |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2018-06-01 |
description |
Iron is a trace element, essential to support life due to its inherent ability to exchange electrons with a variety of molecules. The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic microorganisms and their hosts. During evolution, the shared requirement of micro- and macro-organisms for this important nutrient has shaped the pathogen–host relationship. Infectious pancreatic necrosis virus (IPNv) affects salmonids constituting a sanitary problem for this industry as it has an important impact on post-smolt survival. While immune modulation induced by IPNv infection has been widely characterized on Salmo salar, viral impact on iron host metabolism has not yet been elucidated. In the present work, we evaluate short-term effect of IPNv on several infected tissues from Salmo salar. We observed that IPNv displayed high tropism to headkidney, which directly correlates with a rise in oxidative stress and antiviral responses. Transcriptional profiling on headkidney showed a massive modulation of gene expression, from which biological pathways involved with iron metabolism were remarkable. Our findings suggest that IPNv infection increase oxidative stress on headkidney as a consequence of iron overload induced by a massive upregulation of genes involved in iron metabolism. |
topic |
iron overload electronic paramagnetic resonance spectroscopy nutritional immunity oxidative stress infectious pancreaticc necrosis virus RNA-seq |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2018.01296/full |
work_keys_str_mv |
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