Beyond the Influence of <i>IDH </i>Mutations: Exploring Epigenetic Vulnerabilities in Chondrosarcoma

Beyond the Influence of <i>IDH </i>Mutations: Exploring Epigenetic Vulnerabilities in Chondrosarcoma

Mutations in the isocitrate dehydrogenase (<i>IDH1</i> or <i>IDH2</i>) genes are common in enchondromas and chondrosarcomas, and lead to elevated levels of the oncometabolite D-2-hydroxyglutarate causing widespread changes in the epigenetic landscape of these tumors. With the...

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Bibliographic Details
Main Authors: Sanne Venneker, Alwine B. Kruisselbrink, Zuzanna Baranski, Ieva Palubeckaite, Inge H. Briaire-de Bruijn, Jan Oosting, Pim J. French, Erik H.J. Danen, Judith V.M.G. Bovée
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
sarcoma
enchondroma
chondrosarcoma
isocitrate dehydrogenase
epigenetics
histone deacetylase
Online Access:https://www.mdpi.com/2072-6694/12/12/3589

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