Brown Adipose Tissue and Skeletal Muscle 18F-FDG Activity After a Personalized Cold Exposure Is Not Associated With Cold-Induced Thermogenesis and Nutrient Oxidation Rates in Young Healthy Adults
Cold induced thermogenesis (CIT) in humans results mainly from the combination of both brown adipose tissue (BAT) and skeletal muscle thermogenic activity. The relative contribution of both tissues to CIT and to cold induced nutrient oxidation rates (CI-NUTox) remains, however, to be elucidated. We...
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Frontiers Media S.A.
2018-11-01
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Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.01577/full |
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language |
English |
format |
Article |
sources |
DOAJ |
author |
Guillermo Sanchez-Delgado Borja Martinez-Tellez Borja Martinez-Tellez Yolanda Garcia-Rivero Yolanda Garcia-Rivero Juan M. A. Alcantara Francisco M. Acosta Francisco J. Amaro-Gahete Francisco J. Amaro-Gahete Jose M. Llamas-Elvira Jose M. Llamas-Elvira Jonatan R. Ruiz |
spellingShingle |
Guillermo Sanchez-Delgado Borja Martinez-Tellez Borja Martinez-Tellez Yolanda Garcia-Rivero Yolanda Garcia-Rivero Juan M. A. Alcantara Francisco M. Acosta Francisco J. Amaro-Gahete Francisco J. Amaro-Gahete Jose M. Llamas-Elvira Jose M. Llamas-Elvira Jonatan R. Ruiz Brown Adipose Tissue and Skeletal Muscle 18F-FDG Activity After a Personalized Cold Exposure Is Not Associated With Cold-Induced Thermogenesis and Nutrient Oxidation Rates in Young Healthy Adults Frontiers in Physiology brown fat non-shivering thermogenesis energy expenditure energy balance obesity mild cold |
author_facet |
Guillermo Sanchez-Delgado Borja Martinez-Tellez Borja Martinez-Tellez Yolanda Garcia-Rivero Yolanda Garcia-Rivero Juan M. A. Alcantara Francisco M. Acosta Francisco J. Amaro-Gahete Francisco J. Amaro-Gahete Jose M. Llamas-Elvira Jose M. Llamas-Elvira Jonatan R. Ruiz |
author_sort |
Guillermo Sanchez-Delgado |
title |
Brown Adipose Tissue and Skeletal Muscle 18F-FDG Activity After a Personalized Cold Exposure Is Not Associated With Cold-Induced Thermogenesis and Nutrient Oxidation Rates in Young Healthy Adults |
title_short |
Brown Adipose Tissue and Skeletal Muscle 18F-FDG Activity After a Personalized Cold Exposure Is Not Associated With Cold-Induced Thermogenesis and Nutrient Oxidation Rates in Young Healthy Adults |
title_full |
Brown Adipose Tissue and Skeletal Muscle 18F-FDG Activity After a Personalized Cold Exposure Is Not Associated With Cold-Induced Thermogenesis and Nutrient Oxidation Rates in Young Healthy Adults |
title_fullStr |
Brown Adipose Tissue and Skeletal Muscle 18F-FDG Activity After a Personalized Cold Exposure Is Not Associated With Cold-Induced Thermogenesis and Nutrient Oxidation Rates in Young Healthy Adults |
title_full_unstemmed |
Brown Adipose Tissue and Skeletal Muscle 18F-FDG Activity After a Personalized Cold Exposure Is Not Associated With Cold-Induced Thermogenesis and Nutrient Oxidation Rates in Young Healthy Adults |
title_sort |
brown adipose tissue and skeletal muscle 18f-fdg activity after a personalized cold exposure is not associated with cold-induced thermogenesis and nutrient oxidation rates in young healthy adults |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2018-11-01 |
description |
Cold induced thermogenesis (CIT) in humans results mainly from the combination of both brown adipose tissue (BAT) and skeletal muscle thermogenic activity. The relative contribution of both tissues to CIT and to cold induced nutrient oxidation rates (CI-NUTox) remains, however, to be elucidated. We investigated the association of BAT and skeletal muscle activity after a personalized cold exposure with CIT and CI-NUTox in 57 healthy adults (23.0 ± 2.4 years old; 25.1 ± 4.6 kg/m2; 35 women). BAT and skeletal muscle (paracervical, sternocleidomastoid, scalene, longus colli, trapezius, parathoracic, supraspinatus, subscapular, deltoid, pectoralis major, and triceps brachii) metabolic activity were assessed by means of a 18Fluorodeoxyglucose positron emission tomography-computed tomography scan preceded by a personalized cold exposure. The cold exposure consisted in remaining in a mild cold room for 2 h at 19.5–20°C wearing a water perfused cooling vest set at 3.8°C above the individual shivering threshold. On a separate day, we estimated CIT and CI-NUTox by indirect calorimetry under fasting conditions for 1 h of personalized cold exposure. There was no association of BAT volume or activity with CIT or CI-NUTox (all P > 0.2). Similarly, the skeletal muscle metabolic activity was not associated either with CIT or CI-NUTox (all P > 0.2). The results persisted after controlling for sex, the time of the day, and the date when CIT was assessed. Our results suggest that human BAT activity and skeletal muscle 18F-FDG activity are not associated to CIT in young healthy adults. Inherent limitations of the available radiotracers for BAT detection and muscle activity quantification may explain why we failed to detect a physiologically plausible association. |
topic |
brown fat non-shivering thermogenesis energy expenditure energy balance obesity mild cold |
url |
https://www.frontiersin.org/article/10.3389/fphys.2018.01577/full |
work_keys_str_mv |
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doaj-c0483b03e88f41edb64022c0fec05bd92020-11-24T21:32:25ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-11-01910.3389/fphys.2018.01577416305Brown Adipose Tissue and Skeletal Muscle 18F-FDG Activity After a Personalized Cold Exposure Is Not Associated With Cold-Induced Thermogenesis and Nutrient Oxidation Rates in Young Healthy AdultsGuillermo Sanchez-Delgado0Borja Martinez-Tellez1Borja Martinez-Tellez2Yolanda Garcia-Rivero3Yolanda Garcia-Rivero4Juan M. A. Alcantara5Francisco M. Acosta6Francisco J. Amaro-Gahete7Francisco J. Amaro-Gahete8Jose M. Llamas-Elvira9Jose M. Llamas-Elvira10Jonatan R. Ruiz11PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, SpainPROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, SpainDepartment of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, NetherlandsNuclear Medicine Department, “Virgen de las Nieves” University Hospital, Granada, SpainNuclear Medicine Department, Biohealth Research Institute in Granada (ibs.GRANADA), Granada, SpainPROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, SpainPROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, SpainPROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, SpainDepartament of Medical Physiology, School of Medicine, University of Granada, Granada, SpainNuclear Medicine Department, “Virgen de las Nieves” University Hospital, Granada, SpainNuclear Medicine Department, Biohealth Research Institute in Granada (ibs.GRANADA), Granada, SpainPROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, SpainCold induced thermogenesis (CIT) in humans results mainly from the combination of both brown adipose tissue (BAT) and skeletal muscle thermogenic activity. The relative contribution of both tissues to CIT and to cold induced nutrient oxidation rates (CI-NUTox) remains, however, to be elucidated. We investigated the association of BAT and skeletal muscle activity after a personalized cold exposure with CIT and CI-NUTox in 57 healthy adults (23.0 ± 2.4 years old; 25.1 ± 4.6 kg/m2; 35 women). BAT and skeletal muscle (paracervical, sternocleidomastoid, scalene, longus colli, trapezius, parathoracic, supraspinatus, subscapular, deltoid, pectoralis major, and triceps brachii) metabolic activity were assessed by means of a 18Fluorodeoxyglucose positron emission tomography-computed tomography scan preceded by a personalized cold exposure. The cold exposure consisted in remaining in a mild cold room for 2 h at 19.5–20°C wearing a water perfused cooling vest set at 3.8°C above the individual shivering threshold. On a separate day, we estimated CIT and CI-NUTox by indirect calorimetry under fasting conditions for 1 h of personalized cold exposure. There was no association of BAT volume or activity with CIT or CI-NUTox (all P > 0.2). Similarly, the skeletal muscle metabolic activity was not associated either with CIT or CI-NUTox (all P > 0.2). The results persisted after controlling for sex, the time of the day, and the date when CIT was assessed. Our results suggest that human BAT activity and skeletal muscle 18F-FDG activity are not associated to CIT in young healthy adults. Inherent limitations of the available radiotracers for BAT detection and muscle activity quantification may explain why we failed to detect a physiologically plausible association.https://www.frontiersin.org/article/10.3389/fphys.2018.01577/fullbrown fatnon-shivering thermogenesisenergy expenditureenergy balanceobesitymild cold |