Heparin versus Danaproid for Prevention of Venous Thromboembolism after Hip Surgery

Purpose. To compare the prevalence of deep vein thrombosis (DVT), pulmonary thromboembolism (PTE), and bleeding complications in patients receiving heparin or danaproid after hemiarthroplasty or osteosynthesis for hip fractures. Methods. 37 men and 138 women aged 47 to 100 (mean, 80) years underwent...

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Main Authors: J Nakase, Y Toribatake, Y Mouri, H Seki, K Kitaoka, K Tomita
Format: Article
Language:English
Published: SAGE Publishing 2009-04-01
Series:Journal of Orthopaedic Surgery
Online Access:https://doi.org/10.1177/230949900901700102
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spelling doaj-c057f1d29d7a4f99bcb1dc80ffe634862020-11-25T01:20:38ZengSAGE PublishingJournal of Orthopaedic Surgery2309-49902009-04-011710.1177/230949900901700102Heparin versus Danaproid for Prevention of Venous Thromboembolism after Hip SurgeryJ Nakase0Y Toribatake1Y Mouri2H Seki3K Kitaoka4K Tomita5 Department of Orthopedics, Kouseiren-Takaoka Hospital, Takaoka, Toyama, Japan Department of Orthopedics, Kouseiren-Takaoka Hospital, Takaoka, Toyama, Japan Department of Orthopedics, Kouseiren-Takaoka Hospital, Takaoka, Toyama, Japan Department of Radiology, Kouseiren-Takaoka Hospital, Takaoka, Toyama, Japan Department of Orthopedics, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan Department of Orthopedics, Kanazawa University Hospital, Kanazawa, Ishikawa, JapanPurpose. To compare the prevalence of deep vein thrombosis (DVT), pulmonary thromboembolism (PTE), and bleeding complications in patients receiving heparin or danaproid after hemiarthroplasty or osteosynthesis for hip fractures. Methods. 37 men and 138 women aged 47 to 100 (mean, 80) years underwent either hemiarthroplasty or osteosynthesis for hip fractures; 5 patients with dementia were excluded. All patients received preoperative elastic stocking and postoperative intermittent pneumatic compression. They were divided into 3 groups based on their admission period: controls (n=71), unfractionated heparin (n=44), and danaproid sodium (n=55). Drugs were administered from postoperative day 1 to 7. At day 7, all patients undertook radioisotope venography of the legs and lung perfusion scintigraphy. Results. In the control, heparin, and danaproid groups respectively, the DVT rates were 31%, 9.1%, and 5.5%, and the PTE rates were 5.6%, 4.5%, and 1.8%. Only the DVT rate in the control group was significantly higher than that in the heparin and danaproid groups. In the heparin group, one patient had gastrointestinal bleeding, 5 developed wound haematomas, and one had leakage from the drain site for 2 weeks. Conclusion. Danaproid sodium appeared more effective and safer than heparin, with no bleeding complications occurred.https://doi.org/10.1177/230949900901700102
collection DOAJ
language English
format Article
sources DOAJ
author J Nakase
Y Toribatake
Y Mouri
H Seki
K Kitaoka
K Tomita
spellingShingle J Nakase
Y Toribatake
Y Mouri
H Seki
K Kitaoka
K Tomita
Heparin versus Danaproid for Prevention of Venous Thromboembolism after Hip Surgery
Journal of Orthopaedic Surgery
author_facet J Nakase
Y Toribatake
Y Mouri
H Seki
K Kitaoka
K Tomita
author_sort J Nakase
title Heparin versus Danaproid for Prevention of Venous Thromboembolism after Hip Surgery
title_short Heparin versus Danaproid for Prevention of Venous Thromboembolism after Hip Surgery
title_full Heparin versus Danaproid for Prevention of Venous Thromboembolism after Hip Surgery
title_fullStr Heparin versus Danaproid for Prevention of Venous Thromboembolism after Hip Surgery
title_full_unstemmed Heparin versus Danaproid for Prevention of Venous Thromboembolism after Hip Surgery
title_sort heparin versus danaproid for prevention of venous thromboembolism after hip surgery
publisher SAGE Publishing
series Journal of Orthopaedic Surgery
issn 2309-4990
publishDate 2009-04-01
description Purpose. To compare the prevalence of deep vein thrombosis (DVT), pulmonary thromboembolism (PTE), and bleeding complications in patients receiving heparin or danaproid after hemiarthroplasty or osteosynthesis for hip fractures. Methods. 37 men and 138 women aged 47 to 100 (mean, 80) years underwent either hemiarthroplasty or osteosynthesis for hip fractures; 5 patients with dementia were excluded. All patients received preoperative elastic stocking and postoperative intermittent pneumatic compression. They were divided into 3 groups based on their admission period: controls (n=71), unfractionated heparin (n=44), and danaproid sodium (n=55). Drugs were administered from postoperative day 1 to 7. At day 7, all patients undertook radioisotope venography of the legs and lung perfusion scintigraphy. Results. In the control, heparin, and danaproid groups respectively, the DVT rates were 31%, 9.1%, and 5.5%, and the PTE rates were 5.6%, 4.5%, and 1.8%. Only the DVT rate in the control group was significantly higher than that in the heparin and danaproid groups. In the heparin group, one patient had gastrointestinal bleeding, 5 developed wound haematomas, and one had leakage from the drain site for 2 weeks. Conclusion. Danaproid sodium appeared more effective and safer than heparin, with no bleeding complications occurred.
url https://doi.org/10.1177/230949900901700102
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