GLP-1 Receptor: A New Target for Sepsis

GLP-1 Receptor: A New Target for Sepsis

Patients with sepsis often exhibit hyperglycemia, which increases mortality. glucagon-like peptide-1 receptor agonists (GLP-1RAs) not only regulate blood glucose homeostasis but also improve organ dysfunction, regulate immunity, and control inflammation and other functions in patients with sepsis. H...

Full description

Bibliographic Details
Main Authors: Fuxun Yang, Fan Zeng, Xiaoxiu Luo, Yu Lei, Jiajia Li, Sen Lu, Xiaobo Huang, Yunping Lan, Rongan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
GLP-1 receptor
sepsis
hyperglycemia
GLP-1 receptor agonist
insulin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.706908/full
id doaj-c05a228e42a04f7ab6950d37a4812950
record_format Article
spelling doaj-c05a228e42a04f7ab6950d37a48129502021-07-14T06:42:22ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-07-011210.3389/fphar.2021.706908706908GLP-1 Receptor: A New Target for SepsisFuxun YangFan ZengXiaoxiu LuoYu LeiJiajia LiSen LuXiaobo HuangYunping LanRongan LiuPatients with sepsis often exhibit hyperglycemia, which increases mortality. glucagon-like peptide-1 receptor agonists (GLP-1RAs) not only regulate blood glucose homeostasis but also improve organ dysfunction, regulate immunity, and control inflammation and other functions in patients with sepsis. Here, we review the possible application of GLP-1RAs in sepsis, to provide a new perspective for the clinical diagnosis and treatment of patients with sepsis complicated with stress hyperglycemia.https://www.frontiersin.org/articles/10.3389/fphar.2021.706908/fullGLP-1 receptorsepsishyperglycemiaGLP-1 receptor agonistinsulin
collection DOAJ
language English
format Article
sources DOAJ
author Fuxun Yang
Fan Zeng
Xiaoxiu Luo
Yu Lei
Jiajia Li
Sen Lu
Xiaobo Huang
Yunping Lan
Rongan Liu
spellingShingle Fuxun Yang
Fan Zeng
Xiaoxiu Luo
Yu Lei
Jiajia Li
Sen Lu
Xiaobo Huang
Yunping Lan
Rongan Liu
GLP-1 Receptor: A New Target for Sepsis
Frontiers in Pharmacology
GLP-1 receptor
sepsis
hyperglycemia
GLP-1 receptor agonist
insulin
author_facet Fuxun Yang
Fan Zeng
Xiaoxiu Luo
Yu Lei
Jiajia Li
Sen Lu
Xiaobo Huang
Yunping Lan
Rongan Liu
author_sort Fuxun Yang
title GLP-1 Receptor: A New Target for Sepsis
title_short GLP-1 Receptor: A New Target for Sepsis
title_full GLP-1 Receptor: A New Target for Sepsis
title_fullStr GLP-1 Receptor: A New Target for Sepsis
title_full_unstemmed GLP-1 Receptor: A New Target for Sepsis
title_sort glp-1 receptor: a new target for sepsis
publisher Frontiers Media S.A.
series Frontiers in Pharmacology
issn 1663-9812
publishDate 2021-07-01
description Patients with sepsis often exhibit hyperglycemia, which increases mortality. glucagon-like peptide-1 receptor agonists (GLP-1RAs) not only regulate blood glucose homeostasis but also improve organ dysfunction, regulate immunity, and control inflammation and other functions in patients with sepsis. Here, we review the possible application of GLP-1RAs in sepsis, to provide a new perspective for the clinical diagnosis and treatment of patients with sepsis complicated with stress hyperglycemia.
topic GLP-1 receptor
sepsis
hyperglycemia
GLP-1 receptor agonist
insulin
url https://www.frontiersin.org/articles/10.3389/fphar.2021.706908/full
work_keys_str_mv AT fuxunyang glp1receptoranewtargetforsepsis
AT fanzeng glp1receptoranewtargetforsepsis
AT xiaoxiuluo glp1receptoranewtargetforsepsis
AT yulei glp1receptoranewtargetforsepsis
AT jiajiali glp1receptoranewtargetforsepsis
AT senlu glp1receptoranewtargetforsepsis
AT xiaobohuang glp1receptoranewtargetforsepsis
AT yunpinglan glp1receptoranewtargetforsepsis
AT ronganliu glp1receptoranewtargetforsepsis
_version_ 1721303970082717696

Similar Items