Metal Levels, Genetic Instability, and Renal Markers in Electronic Waste Workers in Thailand
Background: Informal electronic waste (e-waste) recycling is an increasingly important industry worldwide. However, few studies have studied the health risks in this group of workers. Objective: To assess the associations between occupational exposures to metals and genetic instability and renal ma...
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doaj-c06ce7c6f1f1468c9c1416af203d7cb62020-11-25T03:43:05ZengNational Iranian Oil Company (NIOC) Health OrganizationThe International Journal of Occupational and Environmental Medicine2008-65202008-68142020-03-01112 April728410.34172/ijoem.2020.1826387Metal Levels, Genetic Instability, and Renal Markers in Electronic Waste Workers in ThailandRichard L Neitzel0Stephanie K Sayler1Aubrey L Arain2Kowit Nambunmee3University of Michigan School of Public Health, Department of Environmental Health Sciences, 1415 Washington Heights, Ann Arbor, MI 48109, USAUniversity of Michigan School of Public Health, Department of Environmental Health Sciences, 1415 Washington Heights, Ann Arbor, MI 48109, USAUniversity of Michigan School of Public Health, Department of Environmental Health Sciences, 1415 Washington Heights, Ann Arbor, MI 48109, USAMae Fah Luang University, School of Health Science, 333 Moo 1, Thasud, Muang, Chiang Rai 57100, ThailandBackground: Informal electronic waste (e-waste) recycling is an increasingly important industry worldwide. However, few studies have studied the health risks in this group of workers. Objective: To assess the associations between occupational exposures to metals and genetic instability and renal markers among e-waste recycling workers. Methods: We recruited informal e-waste recycling workers from a community in northeastern Thailand. Participants completed a questionnaire, several health measurements, and provided urine and blood samples, which we then analyzed for a number of metals including lead (Pb), cadmium (Cd), and manganese (Mn). Samples were analyzed for a marker of RNA and DNA damage (ie, oxidative stress), 8-hydroxy-2'-deoxyguanosine (8-OHdG). Glomerular filtration rate (GFR) and fractional excretion of calcium (FECa%) were measured as markers of renal function. Correlations and regression models were used to assess associations between these various factors. Results: We found significantly higher levels of Cd and Pb in blood of men compared with those in women. Men who worked >48 hours/week had significantly higher levels of 8-OHdG compared with men who worked ≤48 hours/week. Smoking was significantly associated with higher blood Pb and Cd concentrations among men. Conclusion: Our results suggest gender differences in both blood concentrations of metals associated with e-waste recycling and smoking and highlight potentially elevated oxidative stress associated with longer work hours. Health promotion efforts are needed among informal e-waste recyclers to reduce possible risks of renal damage and cancer.https://www.theijoem.com/ijoem/index.php/ijoem/article/view/1826electronic wasteoxidative stressthailandrenal insufficiencyheavy metal poisoning |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Richard L Neitzel Stephanie K Sayler Aubrey L Arain Kowit Nambunmee |
spellingShingle |
Richard L Neitzel Stephanie K Sayler Aubrey L Arain Kowit Nambunmee Metal Levels, Genetic Instability, and Renal Markers in Electronic Waste Workers in Thailand The International Journal of Occupational and Environmental Medicine electronic waste oxidative stress thailand renal insufficiency heavy metal poisoning |
author_facet |
Richard L Neitzel Stephanie K Sayler Aubrey L Arain Kowit Nambunmee |
author_sort |
Richard L Neitzel |
title |
Metal Levels, Genetic Instability, and Renal Markers in Electronic Waste Workers in Thailand |
title_short |
Metal Levels, Genetic Instability, and Renal Markers in Electronic Waste Workers in Thailand |
title_full |
Metal Levels, Genetic Instability, and Renal Markers in Electronic Waste Workers in Thailand |
title_fullStr |
Metal Levels, Genetic Instability, and Renal Markers in Electronic Waste Workers in Thailand |
title_full_unstemmed |
Metal Levels, Genetic Instability, and Renal Markers in Electronic Waste Workers in Thailand |
title_sort |
metal levels, genetic instability, and renal markers in electronic waste workers in thailand |
publisher |
National Iranian Oil Company (NIOC) Health Organization |
series |
The International Journal of Occupational and Environmental Medicine |
issn |
2008-6520 2008-6814 |
publishDate |
2020-03-01 |
description |
Background: Informal electronic waste (e-waste) recycling is an increasingly important industry worldwide. However, few studies have studied the health risks in this group of workers.
Objective: To assess the associations between occupational exposures to metals and genetic instability and renal markers among e-waste recycling workers.
Methods: We recruited informal e-waste recycling workers from a community in northeastern Thailand. Participants completed a questionnaire, several health measurements, and provided urine and blood samples, which we then analyzed for a number of metals including lead (Pb), cadmium (Cd), and manganese (Mn). Samples were analyzed for a marker of RNA and DNA damage (ie, oxidative stress), 8-hydroxy-2'-deoxyguanosine (8-OHdG). Glomerular filtration rate (GFR) and fractional excretion of calcium (FECa%) were measured as markers of renal function. Correlations and regression models were used to assess associations between these various factors.
Results: We found significantly higher levels of Cd and Pb in blood of men compared with those in women. Men who worked >48 hours/week had significantly higher levels of 8-OHdG compared with men who worked ≤48 hours/week. Smoking was significantly associated with higher blood Pb and Cd concentrations among men.
Conclusion: Our results suggest gender differences in both blood concentrations of metals associated with e-waste recycling and smoking and highlight potentially elevated oxidative stress associated with longer work hours. Health promotion efforts are needed among informal e-waste recyclers to reduce possible risks of renal damage and cancer. |
topic |
electronic waste oxidative stress thailand renal insufficiency heavy metal poisoning |
url |
https://www.theijoem.com/ijoem/index.php/ijoem/article/view/1826 |
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