N-linked glycosylation of the West Nile virus envelope protein is not a requisite for avian virulence or vector competence.

N-linked glycosylation of the West Nile virus envelope protein is not a requisite for avian virulence or vector competence.

The N-linked glycosylation motif at amino acid position 154-156 of the envelope (E) protein of West Nile virus (WNV) is linked to enhanced murine neuroinvasiveness, avian pathogenicity and vector competence. Naturally occurring isolates with altered E protein glycosylation patterns have been observe...

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Main Authors: Payal D Maharaj, Stanley A Langevin, Bethany G Bolling, Christy C Andrade, Xavier A Engle, Wanichaya N Ramey, Angela Bosco-Lauth, Richard A Bowen, Todd A Sanders, Claire Y-H Huang, William K Reisen, Aaron C Brault
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-07-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0007473

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