Methylation in MIRLET7A3 Gene Induces the Expression of IGF-II and Its mRNA Binding Proteins IGF2BP-2 and 3 in Hepatocellular Carcinoma

Methylation in MIRLET7A3 Gene Induces the Expression of IGF-II and Its mRNA Binding Proteins IGF2BP-2 and 3 in Hepatocellular Carcinoma

miR-let-7a is a tumor suppressor miRNA with reduced expression in most cancers. Methylation of MIRLET7A3 gene was reported to be the cause of this suppression in several cancers; however, it was not explicitly investigated in hepatocellular carcinoma (HCC). We aimed at investigating miR-let-7a expre...

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Bibliographic Details
Main Authors: Amr A. Waly, Nada El-Ekiaby, Reem A. Assal, Mohamed M. Abdelrahman, Karim A. Hosny, Hend M. El Tayebi, Gamal Esmat, Kai Breuhahn, Ahmed I. Abdelaziz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Physiology
Subjects:
miR-let-7a
methylation
IGF-II
IGF2BP
HCC
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01918/full

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