IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells

IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells

Background: In inflammatory bowel disease (IBD), cytokine levels (such as interleukin-1 (IL-1)) are elevated. We have shown previously that IL-1 activates phospholipid signaling pathways in intestinal epithelial cells (IEC), leading to increased ceramide levels.

Bibliographic Details
Main Authors: Fadia R. Homaidan, Marwan E. El-Sabban, Iman Chakroun, Mirvat El-Sibai, Ghassan S. Dbaibo
Format: Article
Language:English
Published: Hindawi Limited 2002-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1080/09629350210313
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spelling doaj-c07ad54111f9496b99be7e7848d632292020-11-24T21:04:22ZengHindawi LimitedMediators of Inflammation0962-93511466-18612002-01-01111394510.1080/09629350210313IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cellsFadia R. Homaidan0Marwan E. El-Sabban1Iman Chakroun2Mirvat El-Sibai3Ghassan S. Dbaibo4Department of Physiology, Faculty of Medicine, American University of Beirut, Beirut, LebanonDepartment of Human Morphology, Faculty of Medicine, American University of Beirut, Beirut, LebanonDepartment of Physiology, Faculty of Medicine, American University of Beirut, Beirut, LebanonDepartment of Physiology, Faculty of Medicine, American University of Beirut, Beirut, LebanonDepartment of Pediatrics, Faculty of Medicine, American University of Beirut, Beirut, LebanonBackground: In inflammatory bowel disease (IBD), cytokine levels (such as interleukin-1 (IL-1)) are elevated. We have shown previously that IL-1 activates phospholipid signaling pathways in intestinal epithelial cells (IEC), leading to increased ceramide levels.http://dx.doi.org/10.1080/09629350210313
collection DOAJ
language English
format Article
sources DOAJ
author Fadia R. Homaidan
Marwan E. El-Sabban
Iman Chakroun
Mirvat El-Sibai
Ghassan S. Dbaibo
spellingShingle Fadia R. Homaidan
Marwan E. El-Sabban
Iman Chakroun
Mirvat El-Sibai
Ghassan S. Dbaibo
IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells
Mediators of Inflammation
author_facet Fadia R. Homaidan
Marwan E. El-Sabban
Iman Chakroun
Mirvat El-Sibai
Ghassan S. Dbaibo
author_sort Fadia R. Homaidan
title IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells
title_short IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells
title_full IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells
title_fullStr IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells
title_full_unstemmed IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells
title_sort il-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells
publisher Hindawi Limited
series Mediators of Inflammation
issn 0962-9351
1466-1861
publishDate 2002-01-01
description Background: In inflammatory bowel disease (IBD), cytokine levels (such as interleukin-1 (IL-1)) are elevated. We have shown previously that IL-1 activates phospholipid signaling pathways in intestinal epithelial cells (IEC), leading to increased ceramide levels.
url http://dx.doi.org/10.1080/09629350210313
work_keys_str_mv AT fadiarhomaidan il1stimulatesceramideaccumulationwithoutinducingapoptosisinintestinalepithelialcells
AT marwaneelsabban il1stimulatesceramideaccumulationwithoutinducingapoptosisinintestinalepithelialcells
AT imanchakroun il1stimulatesceramideaccumulationwithoutinducingapoptosisinintestinalepithelialcells
AT mirvatelsibai il1stimulatesceramideaccumulationwithoutinducingapoptosisinintestinalepithelialcells
AT ghassansdbaibo il1stimulatesceramideaccumulationwithoutinducingapoptosisinintestinalepithelialcells
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