Dengue and Chikungunya Virus Infections among Young Febrile Adults Evaluated for Acute HIV-1 Infection in Coastal Kenya.
BACKGROUND:Fever is common among patients seeking care in sub-Saharan Africa (sSA), but causes other than malaria are rarely diagnosed. We assessed dengue and chikungunya virus infections among young febrile adults evaluated for acute HIV infection (AHI) and malaria in coastal Kenya. METHODS:We test...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5152832?pdf=render |
id |
doaj-c08de5dd30984e098202af8e4f68ed78 |
---|---|
record_format |
Article |
spelling |
doaj-c08de5dd30984e098202af8e4f68ed782020-11-24T21:09:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011112e016750810.1371/journal.pone.0167508Dengue and Chikungunya Virus Infections among Young Febrile Adults Evaluated for Acute HIV-1 Infection in Coastal Kenya.Carolyne N NgoiMatt A PriceBarry FieldsJuma BonventureCaroline OchiengGrace MwashigadiAmin S HassanAlexander N Thiong'oMurugi MicheniPeter MugoSusan GrahamEduard J SandersBACKGROUND:Fever is common among patients seeking care in sub-Saharan Africa (sSA), but causes other than malaria are rarely diagnosed. We assessed dengue and chikungunya virus infections among young febrile adults evaluated for acute HIV infection (AHI) and malaria in coastal Kenya. METHODS:We tested plasma samples obtained in a cross-sectional study from febrile adult patients aged 18-35 years evaluated for AHI and malaria at urgent care seeking at seven health facilities in coastal Kenya in 2014-2015. Dengue virus (DENV) and chikungunya virus (CHIKV) were amplified using quantitative real-time reverse-transcription polymerase chain reaction. We conducted logistic regression analyses to determine independent predictors of dengue virus infection. RESULTS:489 samples that were negative for both AHI and malaria were tested, of which 43 (8.8%, 95% confidence interval [CI]: 6.4-11.7) were positive for DENV infection. No participant was positive for CHIKV infection. DENV infections were associated with clinic visits in the rainy season (adjusted odds ratio (AOR) = 3.0, 95% CI: 1.3-6.5) and evaluation at a private health facility (AOR 5.2, 95% CI: 2.0-13.1) or research health facility (AOR = 25.6, 95% CI: 8.9-73.2) instead of a public health facility. CONCLUSION:A high prevalence of DENV infections was found in febrile young adult patients evaluated for AHI. Our data suggests that DENV, along with AHI and malaria, should be considered in the differential diagnosis of the adult patient seeking care for fever in coastal Kenya.http://europepmc.org/articles/PMC5152832?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carolyne N Ngoi Matt A Price Barry Fields Juma Bonventure Caroline Ochieng Grace Mwashigadi Amin S Hassan Alexander N Thiong'o Murugi Micheni Peter Mugo Susan Graham Eduard J Sanders |
spellingShingle |
Carolyne N Ngoi Matt A Price Barry Fields Juma Bonventure Caroline Ochieng Grace Mwashigadi Amin S Hassan Alexander N Thiong'o Murugi Micheni Peter Mugo Susan Graham Eduard J Sanders Dengue and Chikungunya Virus Infections among Young Febrile Adults Evaluated for Acute HIV-1 Infection in Coastal Kenya. PLoS ONE |
author_facet |
Carolyne N Ngoi Matt A Price Barry Fields Juma Bonventure Caroline Ochieng Grace Mwashigadi Amin S Hassan Alexander N Thiong'o Murugi Micheni Peter Mugo Susan Graham Eduard J Sanders |
author_sort |
Carolyne N Ngoi |
title |
Dengue and Chikungunya Virus Infections among Young Febrile Adults Evaluated for Acute HIV-1 Infection in Coastal Kenya. |
title_short |
Dengue and Chikungunya Virus Infections among Young Febrile Adults Evaluated for Acute HIV-1 Infection in Coastal Kenya. |
title_full |
Dengue and Chikungunya Virus Infections among Young Febrile Adults Evaluated for Acute HIV-1 Infection in Coastal Kenya. |
title_fullStr |
Dengue and Chikungunya Virus Infections among Young Febrile Adults Evaluated for Acute HIV-1 Infection in Coastal Kenya. |
title_full_unstemmed |
Dengue and Chikungunya Virus Infections among Young Febrile Adults Evaluated for Acute HIV-1 Infection in Coastal Kenya. |
title_sort |
dengue and chikungunya virus infections among young febrile adults evaluated for acute hiv-1 infection in coastal kenya. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
BACKGROUND:Fever is common among patients seeking care in sub-Saharan Africa (sSA), but causes other than malaria are rarely diagnosed. We assessed dengue and chikungunya virus infections among young febrile adults evaluated for acute HIV infection (AHI) and malaria in coastal Kenya. METHODS:We tested plasma samples obtained in a cross-sectional study from febrile adult patients aged 18-35 years evaluated for AHI and malaria at urgent care seeking at seven health facilities in coastal Kenya in 2014-2015. Dengue virus (DENV) and chikungunya virus (CHIKV) were amplified using quantitative real-time reverse-transcription polymerase chain reaction. We conducted logistic regression analyses to determine independent predictors of dengue virus infection. RESULTS:489 samples that were negative for both AHI and malaria were tested, of which 43 (8.8%, 95% confidence interval [CI]: 6.4-11.7) were positive for DENV infection. No participant was positive for CHIKV infection. DENV infections were associated with clinic visits in the rainy season (adjusted odds ratio (AOR) = 3.0, 95% CI: 1.3-6.5) and evaluation at a private health facility (AOR 5.2, 95% CI: 2.0-13.1) or research health facility (AOR = 25.6, 95% CI: 8.9-73.2) instead of a public health facility. CONCLUSION:A high prevalence of DENV infections was found in febrile young adult patients evaluated for AHI. Our data suggests that DENV, along with AHI and malaria, should be considered in the differential diagnosis of the adult patient seeking care for fever in coastal Kenya. |
url |
http://europepmc.org/articles/PMC5152832?pdf=render |
work_keys_str_mv |
AT carolynenngoi dengueandchikungunyavirusinfectionsamongyoungfebrileadultsevaluatedforacutehiv1infectionincoastalkenya AT mattaprice dengueandchikungunyavirusinfectionsamongyoungfebrileadultsevaluatedforacutehiv1infectionincoastalkenya AT barryfields dengueandchikungunyavirusinfectionsamongyoungfebrileadultsevaluatedforacutehiv1infectionincoastalkenya AT jumabonventure dengueandchikungunyavirusinfectionsamongyoungfebrileadultsevaluatedforacutehiv1infectionincoastalkenya AT carolineochieng dengueandchikungunyavirusinfectionsamongyoungfebrileadultsevaluatedforacutehiv1infectionincoastalkenya AT gracemwashigadi dengueandchikungunyavirusinfectionsamongyoungfebrileadultsevaluatedforacutehiv1infectionincoastalkenya AT aminshassan dengueandchikungunyavirusinfectionsamongyoungfebrileadultsevaluatedforacutehiv1infectionincoastalkenya AT alexandernthiongo dengueandchikungunyavirusinfectionsamongyoungfebrileadultsevaluatedforacutehiv1infectionincoastalkenya AT murugimicheni dengueandchikungunyavirusinfectionsamongyoungfebrileadultsevaluatedforacutehiv1infectionincoastalkenya AT petermugo dengueandchikungunyavirusinfectionsamongyoungfebrileadultsevaluatedforacutehiv1infectionincoastalkenya AT susangraham dengueandchikungunyavirusinfectionsamongyoungfebrileadultsevaluatedforacutehiv1infectionincoastalkenya AT eduardjsanders dengueandchikungunyavirusinfectionsamongyoungfebrileadultsevaluatedforacutehiv1infectionincoastalkenya |
_version_ |
1716757045636497408 |